This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging
Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across …

A key objective in the field of translational psychiatry over the past few decades has been to
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …

Left–right asymmetry of the human brain is one of its cardinal features, and also a complex,
multivariate trait. Decades of research have suggested that brain asymmetry may be altered …

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological, …

Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …

Through harmonized procedures and by sharing site-specific brain metrics (for example,
cortical thickness) or aggregated statistical maps, ENIGMA has set the stage for large-scale …

Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing
multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations …

Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

Importance Large-scale neuroimaging studies have revealed group differences in cortical
thickness across many psychiatric disorders. The underlying neurobiology behind these …

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy,
aging-related diseases, and mortality. We examined potential advanced brain aging in adult …