DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genetic instability.
To preserve genome integrity, organisms have evolved several DSB repair mechanisms, of …

DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic integrity
and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important regulator …

Inherited germline mutations in either BRCA1 or BRCA2 confer a significant lifetime risk of
developing breast or ovarian cancer. Defining how these two genes function at the cellular …

Large-scale genomic studies have shown that half of epithelial ovarian cancers (EOCs)
have alterations in genes regulating homologous recombination (HR) repair 1 . Loss of HR …

… Boulton 1 and … All strains were checked by PCR screening as described previously (Boulton
and … (CRC; grants SP2143/0103), and SJBoulton is supported by a CRC studentship. …

The appropriate execution of DNA double-strand break (DSB) repair is critical for genome
stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway …

… SJBoulton and SPJackson … Although no DNA-PKCS homologue appears to exist in S.cerei'isiae
by strict sequence criteria (SJBoulton and SPJackson, unpublished data), S.cerex'isiae …

Posttranslational modifications play key roles in regulating chromatin plasticity. Although
various chromatin-remodeling enzymes have been described that respond to specific histone …

Ku is a heterodimer of polypeptides of approximately 70 and 80 kDa (Ku70 and Ku80,
respectively) that binds to DNA ends. Mammalian cells lacking Ku are defective in DNA double-…

To identify approaches to target DNA repair vulnerabilities in cancer, we discovered
nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase …