Mutations in ELA2 encoding the neutrophil granule protease, neutrophil elastase (NE), are
the major cause of the 2 main forms of hereditary neutropenia, cyclic neutropenia and severe …

BACKGROUND The PCR and its variant, quantitative PCR (qPCR), have revolutionized the
practice of clinical microbiology. Continued advancements in PCR have led to a new …

Microsatellite instability (MSI), the spontaneous loss or gain of nucleotides from repetitive
DNA tracts, is a diagnostic phenotype for gastrointestinal, endometrial, and colorectal tumors, …

To understand the genetic drivers of immune recognition and evasion in colorectal cancer,
we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as …

BACKGROUND Microsatellite instability (MSI) is a useful phenotype in cancer diagnosis
and prognosis. Nevertheless, methods to detect MSI status from next generation DNA …

The detection and quantification of genetic heterogeneity in populations of cells is fundamentally
important to diverse fields, ranging from microbial evolution to human cancer genetics. …

Molecular methods can enable rapid identification of Bartonella spp. infections, which are
difficult to diagnose by using culture or serology. We analyzed clinical test results of PCR that …

High-throughput sequencing of the taxonomically informative 16S rRNA gene provides a
powerful approach for exploring microbial diversity. Here we compare the performances of two …

Nosocomial infections pose a significant threat to patient health; however, the gold standard
laboratory method for determining bacterial relatedness (pulsed-field gel electrophoresis […

To catalog protein-altering mutations that may drive the development of prostate cancers
and their progression to metastatic disease systematically, we performed whole-exome …