Targeted nucleases have provided researchers with the ability to manipulate virtually any
genomic sequence, enabling the facile creation of isogenic cell lines and animal models for …

Site‐specific recombinases are tremendously valuable tools for basic research and genetic
engineering. By promoting high‐fidelity DNA modifications, site‐specific recombination …

Zinc-finger nucleases (ZFNs) are versatile reagents that have redefined genome engineering.
Realizing the full potential of this technology requires the development of safe and …

Transcription activator-like (TAL) effector nucleases (TALENs) have enabled the introduction
of targeted genetic alterations into a broad range of cell lines and organisms. These …

Consumption of glucosinolates, pro-drug-like metabolites abundant in Brassica vegetables,
has been associated with decreased risk of certain cancers. Gut microbiota have the ability …

Modern medicine has long studied the mechanism and impact of pathogenic microbes on
human hosts, but has only recently shifted attention toward the complex and vital roles that …

The development of new methods for delivering proteins into cells is a central challenge for
advancing both basic research and therapeutic applications. We previously reported that zinc…

Rapid clearing engineered antibody fragments for immunoPET promise high sensitivity at
early time points. Here, tumor targeting of anti-CD20 diabodies (scFv dimers) for detection of …

Zinc-finger recombinases (ZFRs) represent a potentially powerful class of tools for targeted
genetic engineering. These chimeric enzymes are composed of an activated catalytic domain …

Combining the specificity of tumor-targeting antibodies with the sensitivity and quantification
offered by positron emission tomography (PET) provides tremendous opportunities for …