Alterations of the ets family transcription factor ETV6 (TEL) and the RUNT domain transcription
factor RUNX1 (AML1) play pivotal roles in the leukemogenesis of various types of …

Chronic myeloid leukemia (CML) is characterized by the presence of at(9;22)(q34;q11.2),
which leads to the well‐known BCR–ABL1 fusion protein. We describe a patient who was …

There is experimental and observational evidence that the cells of the leukemic clone in
acute myeloid leukemia (AML) have different phenotypes even though they share the same …

Xenograft studies indicate that some solid tumors and leukemias are organized as cellular
hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model, its …

Chromosomal rearrangements involving band 12p13 are found in a wide variety of human
leukemias but are particularly common in childhood acute lymphoblastic leukemia. The …

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, whereas acute
myeloid leukemia (AML) is the most common acute leukemia in adults. In general, ALL has a …

MicroRNAs (miRNAs) are postulated to be important regulators in cancers. Here, we report
a genome-wide miRNA expression analysis in 52 acute myeloid leukemia (AML) samples …

The clinical and prognostic relevance of many recently identified driver gene mutations in
adult acute myeloid leukemia (AML) is poorly defined. We sequenced the coding regions or …

Patients with cytogenetically normal acute myeloid leukemia (CN-AML) show heterogeneous
treatment outcomes. We used gene-expression profiling to develop a gene signature that …

Purpose CEBPA mutations are found as either biallelic (biCEBPA) or monoallelic (moCEBPA).
We set out to explore whether the kind of CEBPA mutation is of prognostic relevance in …