Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as
BCR-ABL1–like ALL, is a high-risk subset with a gene expression profile that shares …

Relapsed and chemotherapy-refractory B-cell acute lymphoblastic leukemia (B-ALL) remain
significant causes of cancer-associated morbidity and mortality for children and adults. …

Background Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, …

A complex interplay of intracellular signaling networks orchestrates normal cell growth and
survival, including translation, transcription, proliferation, and cell cycle progression. …

Pediatric acute lymphoblastic leukemia (ALL) is a heterogeneous disease consisting of
distinct clinical and biological subtypes that are characterized by specific chromosomal …

Many patients with acute myeloid leukemia (AML) are incurable with chemotherapy and
may benefit from novel approaches. One such approach involves the transfer of T cells …

CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified
in Philadelphia chromosome (Ph)–like acute lymphoblastic leukemia (ALL), a recently …

As controversy exists regarding the prognostic significance of genomic rearrangements of
CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/…

Adults and children with high-risk CRLF2-rearranged acute lymphoblastic leukemia (ALL)
respond poorly to current cytotoxic chemotherapy and suffer unacceptably high rates of …

Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a recently described subtype
of T-ALL characterized by a unique immunophenotype and genomic profile, as well as a …