Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual β-adrenergic …
SM Pogwizd, K Schlotthauer, L Li, W Yuan… - Circulation …, 2001 - Am Heart Assoc
Ventricular arrhythmias and contractile dysfunction are the main causes of death in human
heart failure (HF). In a rabbit HF model reproducing these same aspects of human HF, we …
heart failure (HF). In a rabbit HF model reproducing these same aspects of human HF, we …
Ca2+/Calmodulin–Dependent Protein Kinase Modulates Cardiac Ryanodine Receptor Phosphorylation and Sarcoplasmic Reticulum Ca2+ Leak in Heart Failure
…, TR Shannon, DM Bers, SM Pogwizd - Circulation …, 2005 - Am Heart Assoc
Abnormal release of Ca from sarcoplasmic reticulum (SR) via the cardiac ryanodine receptor
(RyR2) may contribute to contractile dysfunction and arrhythmogenesis in heart failure (HF)…
(RyR2) may contribute to contractile dysfunction and arrhythmogenesis in heart failure (HF)…
Upregulation of Na+/Ca2+ Exchanger Expression and Function in an Arrhythmogenic Rabbit Model of Heart Failure
SM Pogwizd, M Qi, W Yuan, AM Samarel… - Circulation …, 1999 - Am Heart Assoc
… Using 3D cardiac mapping, Pogwizd 5 has demonstrated that the spontaneously-occurring
VT in these HF rabbits initiates by a nonreentrant mechanism. Recent 3D mapping studies in …
VT in these HF rabbits initiates by a nonreentrant mechanism. Recent 3D mapping studies in …
Cellular basis of triggered arrhythmias in heart failure
SM Pogwizd, DM Bers - Trends in cardiovascular medicine, 2004 - Elsevier
Ventricular tachycardia in nonischemic heart failure (HF) initiates by a nonreentrant mechanism
that appears to be due to triggered activity primarily from delayed afterdepolarizations …
that appears to be due to triggered activity primarily from delayed afterdepolarizations …
Intracellular Na+ Concentration Is Elevated in Heart Failure But Na/K Pump Function Is Unchanged
… A, Typical control (Ctl) and HF AP at 1 Hz (control AP is from Pogwizd et al 19 ; HF AP was
simulated by extending plateau phase by 42 ms). B, [Ca 2+ ] sm in control and HF calculated …
simulated by extending plateau phase by 42 ms). B, [Ca 2+ ] sm in control and HF calculated …
Elevated Sarcoplasmic Reticulum Ca2+ Leak in Intact Ventricular Myocytes From Rabbits in Heart Failure
TR Shannon, SM Pogwizd, DM Bers - Circulation research, 2003 - Am Heart Assoc
Altered sarcoplasmic reticulum (SR) Ca 2+ -ATPase and Na + -Ca 2+ exchange (NCX)
function have been implicated in depressing SR Ca 2+ content and contractile function in heart …
function have been implicated in depressing SR Ca 2+ content and contractile function in heart …
Reentrant and focal mechanisms underlying ventricular tachycardia in the human heart.
SM Pogwizd, RH Hoyt, JE Saffitz, PB Corr, JL Cox… - Circulation, 1992 - Am Heart Assoc
BACKGROUND To determine the mechanisms of ventricular tachycardia (VT) in humans,
three-dimensional intraoperative mapping of up to 156 intramural sites was performed in 13 …
three-dimensional intraoperative mapping of up to 156 intramural sites was performed in 13 …
Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy
SM Pogwizd, JP McKenzie, ME Cain - Circulation, 1998 - Am Heart Assoc
Background—To define the electrophysiological mechanism(s) of inducible and spontaneously
occurring ventricular arrhythmias associated with nonischemic cardiomyopathy, 3-…
occurring ventricular arrhythmias associated with nonischemic cardiomyopathy, 3-…
Role of RyR2 phosphorylation at S2814 during heart failure progression
Rationale: Increased activity of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is
thought to promote heart failure (HF) progression. However, the importance of CaMKII …
thought to promote heart failure (HF) progression. However, the importance of CaMKII …
Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A
X Ai, SM Pogwizd - Circulation research, 2005 - Am Heart Assoc
In nonischemic heart failure (HF), ventricular tachycardia initiates by a nonreentrant
mechanism, but there is altered conduction (that could lead to re-entry) that could arise from …
mechanism, but there is altered conduction (that could lead to re-entry) that could arise from …