User profiles for S. M. Purcell
Shaun PurcellSleep & Neurogenetics Lab, Brigham & Women's Hospital, Boston Verified email at bwh.harvard.edu Cited by 165301 |
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
…, MJ Daly, SM Purcell, P Sklar, SM Purcell… - Nature, 2009 - nature.com
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …
Second-generation PLINK: rising to the challenge of larger and richer datasets
… Shaun M Purcell , Shaun M Purcell … Christopher C Chang, Carson C Chow, Laurent CAM
Tellier, Shashaank Vattikuti, Shaun M Purcell, James J Lee, Second-generation PLINK: rising …
Tellier, Shashaank Vattikuti, Shaun M Purcell, James J Lee, Second-generation PLINK: rising …
[HTML][HTML] Analysis of protein-coding genetic variation in 60,706 humans
Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …
functional interpretation of DNA sequence changes. Here we describe the aggregation and …
Biological insights from 108 schizophrenia-associated genetic loci
…, J Powell, A Price, AE Pulver, SM Purcell… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
[HTML][HTML] Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
Background Cancers arise from multiple acquired mutations, which presumably occur over
many years. Early stages in cancer development might be present years before cancers …
many years. Early stages in cancer development might be present years before cancers …
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
…, WJ Peyrot, G Pistis, D Posthuma, SM Purcell… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
De novo mutations in schizophrenia implicate synaptic networks
Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …
variation is unique to individual disorders or shared across disorders is unclear. To examine …
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
…, HM Gurling, MJ Owen, SM Purcell… - Nature …, 2008 - nature.com
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…
A polygenic burden of rare disruptive mutations in schizophrenia
Schizophrenia is a common disease with a complex aetiology, probably involving multiple
and heterogeneous genetic factors. Here, by analysing the exome sequences of 2,536 …
and heterogeneous genetic factors. Here, by analysing the exome sequences of 2,536 …