User profiles for S. M. Purcell

Shaun Purcell

Sleep & Neurogenetics Lab, Brigham & Women's Hospital, Boston
Verified email at bwh.harvard.edu
Cited by 165301

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

…, MJ Daly, SM Purcell, P Sklar, SM Purcell… - Nature, 2009 - nature.com
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …

Second-generation PLINK: rising to the challenge of larger and richer datasets

…, CC Chow, LCAM Tellier, S Vattikuti, SM Purcell… - …, 2015 - academic.oup.com
… Shaun M Purcell , Shaun M Purcell … Christopher C Chang, Carson C Chow, Laurent CAM
Tellier, Shashaank Vattikuti, Shaun M Purcell, James J Lee, Second-generation PLINK: rising …

[HTML][HTML] Analysis of protein-coding genetic variation in 60,706 humans

…, R McPherson, BM Neale, A Palotie, SM Purcell… - Nature, 2016 - nature.com
Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Biological insights from 108 schizophrenia-associated genetic loci

…, J Powell, A Price, AE Pulver, SM Purcell… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

[HTML][HTML] Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

…, E Mick, BM Neale, M Fromer, SM Purcell… - … England Journal of …, 2014 - Mass Medical Soc
Background Cancers arise from multiple acquired mutations, which presumably occur over
many years. Early stages in cancer development might be present years before cancers …

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

…, WJ Peyrot, G Pistis, D Posthuma, SM Purcell… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

De novo mutations in schizophrenia implicate synaptic networks

…, P Holmans, P Sklar, MJ Owen, SM Purcell… - Nature, 2014 - nature.com
Inherited alleles account for most of the genetic risk for schizophrenia. However, new (de
novo) mutations, in the form of large chromosomal copy number changes, occur in a small …

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

…, S Ripke, BM Neale, SV Faraone, SM Purcell… - Nature …, 2013 - cdr.lib.unc.edu
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

…, HM Gurling, MJ Owen, SM Purcell… - Nature …, 2008 - nature.com
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…

A polygenic burden of rare disruptive mutations in schizophrenia

SM Purcell, JL Moran, M Fromer, D Ruderfer… - Nature, 2014 - nature.com
Schizophrenia is a common disease with a complex aetiology, probably involving multiple
and heterogeneous genetic factors. Here, by analysing the exome sequences of 2,536 …