Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal
expansion of blood cells. Somatic gene mutations associated with hematologic malignancies …

Background : Familial combined hypolipidemia, a Mendelian condition characterized by
substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the …

Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for
five vascular diseases, including coronary artery disease, migraine headache, cervical artery …

Importance In observational studies, abdominal adiposity has been associated with type 2
diabetes and coronary heart disease (CHD). Whether these associations represent causal …

SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the
disease and potential treatment options remains limited. The infection occurs through binding of …

Importance Recent guidelines endorse using history of menopause before age 40 years to
refine atherosclerotic cardiovascular disease risk assessments among middle-aged women. …

Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to
infectious disease risk are incompletely understood. Age-related mosaic chromosomal …

Transcriptome-wide association analysis is a powerful approach to studying the genetic
architecture of complex traits. A key component of this approach is to build a model to impute …

Background: The relative prevalence and clinical importance of monogenic mutations related
to familial hypercholesterolemia and of high polygenic score (cumulative impact of many …