PTB (polypyrimidine tract-binding protein) is a repressive regulator of alternative splicing.
We have investigated the role of PTB in three model alternative splicing systems. In the α-…

Tumors are prime examples of cell growth in unfavorable environments that elicit cellular
stress. The high metabolic demand and insufficient vascularization of tumors cause a …

The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular
senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of …

Alternative splicing regulation has been shown to be critically important for several developmental
pathways. It is particularly prevalent in the testis, which is the site of an extensive adult …

Mammalian target of rapamycin complex 1 (mTORC1) controls growth and survival in response
to metabolic cues. Oxidative stress affects mTORC1 via inhibitory and stimulatory inputs. …

Mutations in pre-mRNA processing factors (PRPFs) cause autosomal-dominant retinitis
pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed genes cause non-…

Coacervates droplets have long been considered as potential protocells to mimic living cells.
However, these droplets lack a membrane and are prone to coalescence, limiting their …

The ESCRT-III membrane fission machinery maintains the integrity of the nuclear envelope.
Although primary nuclei resealing takes minutes, micronuclear envelope ruptures seem to …

Background The three consensus elements at the 3' end of human introns - the branch point
sequence, the polypyrimidine tract, and the 3' splice site AG dinucleotide - are usually …

Meiosis requires conserved transcriptional changes, but it is not known whether there is a
corresponding set of RNA splicing switches. Here, we used RNAseq of mouse testis to identify …