The oxidation and nitration of unsaturated fatty acids by oxides of nitrogen yield electrophilic
derivatives that can modulate protein function via post-translational protein modifications. …

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite
interactions that mediate these networks are frequently low affinity and …

The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs
in response to infection with DNA viruses and to presence of host DNA in the cytosol. …

Nitro-fatty acids (NO 2 -FA) are pleiotropic modulators of redox signaling pathways. Their
effects on inflammatory signaling have been studied in great detail in cell, animal and clinical …

Aims Electrophilic fatty acid nitroalkene derivatives, products of unsaturated fatty acid
nitration, exert long-term cardiovascular protection in experimental models of metabolic and …

Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the
Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO 2 − )-…

A gap in our understanding of the beneficial systemic responses to dietary constituents
nitrate (NO 3 − ), nitrite (NO 2 − ) and conjugated linoleic acid (cLA) is the identification of the …

The oxidation and nitration of unsaturated fatty acids transforms cell membrane and lipoprotein
constituents into mediators that regulate signal transduction. The formation of 9-NO 2 -…

Although it is well established that many glutamatergic neurons sequester Zn 2+ within their
synaptic vesicles, the physiological significance of synaptic Zn 2+ remains poorly understood…

Conjugated linoleic acid (CLA) is a prime substrate for intra-gastric nitration giving rise to
the formation of nitro-conjugated linoleic acid (NO 2 -CLA). Herein, NO 2 -CLA generation is …