User profiles for S. S. Lakdawala

Seema S Lakdawala

University of Pittsburgh School of Medicine
Verified email at pitt.edu
Cited by 3789

Airborne transmission of respiratory viruses

…, KA Prather, J Sznitman, JL Jimenez, SS Lakdawala… - Science, 2021 - science.org
BACKGROUND Exposure to droplets produced in the coughs and sneezes of infected
individuals or contact with droplet-contaminated surfaces (fomites) have been widely perceived …

Mechanistic insights into the effect of humidity on airborne influenza virus survival, transmission and incidence

…, J Van Mullekom, SS Lakdawala - Journal of the …, 2019 - royalsocietypublishing.org
… [2] studied the inactivation of influenza virus on stainless steel surfaces and found that ‘The
multiple linear regression model including independent variables for RH, temperature, and …

[HTML][HTML] Viral and host heterogeneity and their effects on the viral life cycle

JE Jones, V Le Sage, SS Lakdawala - Nature Reviews Microbiology, 2021 - nature.com
Traditionally, the viral replication cycle is envisioned as a single, well-defined loop with four
major steps: attachment and entry into a target cell, replication of the viral genome, …

A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes

…, LH Moncla, YK Tam, SHY Fan, SS Lakdawala… - Science, 2022 - science.org
Seasonal influenza vaccines offer little protection against pandemic influenza virus strains.
It is difficult to create effective prepandemic vaccines because it is uncertain which influenza …

Influenza virus infectivity is retained in aerosols and droplets independent of relative humidity

…, SS Cox, MM Myerburg, SS Lakdawala… - The Journal of …, 2018 - academic.oup.com
… 225−9551; SKC) installed in stainless steel holders (catalog number 304500; Advantec), at
a … We thank the members of the Marr and Lakdawala laboratories and Dr Peter Vikesland, for …

[HTML][HTML] Eurasian-origin gene segments contribute to the transmissibility, aerosol release, and morphology of the 2009 pandemic H1N1 influenza virus

SS Lakdawala, EW Lamirande, AL Suguitan Jr… - PLoS …, 2011 - journals.plos.org
… Briefly, large stainless steel ventilated ferret cages from Allentown (Allentown, New Jersey)
… (B) and a perforated stainless steel panel (C) prevented any contact between the ferrets. …

The search for a COVID-19 animal model

SS Lakdawala, VD Menachery - Science, 2020 - science.org
As the pandemic caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2)
continues to cause worldwide upheaval, scientists are racing to find appropriate animal …

[HTML][HTML] The soft palate is an important site of adaptation for transmissible influenza viruses

SS Lakdawala, A Jayaraman, RA Halpin… - Nature, 2015 - nature.com
… Twenty-four hours post-infection, a naive animal (airborne-contact) was placed into the
transmission cage on the other side of a perforated stainless steel barrier. The airborne-contact …

[HTML][HTML] Influenza a virus assembly intermediates fuse in the cytoplasm

SS Lakdawala, Y Wu, P Wawrzusin, J Kabat… - PLoS …, 2014 - journals.plos.org
Reassortment of influenza viral RNA (vRNA) segments in co-infected cells can lead to the
emergence of viruses with pandemic potential. Replication of influenza vRNA occurs in the …

Genome-wide analysis of influenza viral RNA and nucleoprotein association

…, DJ Snyder, VS Cooper, SS Lakdawala - Nucleic acids …, 2017 - academic.oup.com
Lakdawala, Genome-wide analysis of influenza viral RNA and nucleoprotein association,
Nucleic Acids Research… We thank members of the Lakdawala laboratory for critical discussion. …