Ageing is accompanied by a steady decline in touch sensitivity and acuity. Conversely,
pleasant touch, such as experienced during a caress, is even more pleasant in old age. There …

… : HO, SSN, and AGM developed the experimental protocol with input from FM and MTSSN,
AGM, EJ, and AM performed the microneurography experiments with assistance from SS and …

Background C‐tactile ( CT ) afferents are unmyelinated low‐threshold mechanoreceptors
optimized for signalling affective, gentle touch. In three separate psychophysical experiments, …

Touch is a powerful communication tool, but we have a limited understanding of the role played
by particular physical features of interpersonal touch communication. In this study, adults …

Non‐technical summary What triggers a realignment of sensations, eg a stimulus that is
perceived as non‐painful in intact skin, but evokes pain in sunburned skin, is yet to be …

Patients with bi-allelic loss of function mutations in the voltage-gated sodium channel Na v
1.7 present with congenital insensitivity to pain (CIP), whilst low threshold mechanosensation …

Social touch is important for interpersonal interaction. Gentle touch and slow brushing are
typically perceived as pleasant, the degree of pleasantness is linked to the activity of the C-…

… The PSE values obtained with sinusoidal stimuli (SS condition) using six sinusoidal … to
comparison stimuli with pulsatile waveforms; SS, in which a sinusoidal test was compared to …

Highlights • Human and animal studies suggest a possible role for C-LTMRs in allodynia. •
Activation of C-LTMRs may also alleviate pain in some contexts. • Diverse synaptic and non-…

… This work was supported by the International Association for the Study of Pain Early Career
Research Grant (P00022261) awarded to SS Nagi. The other authors have no conflicts of …