[HTML][HTML] Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris: The Tabula Muris Consortium
We have created a compendium of single cell transcriptomic data from the model organism
Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data …
Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data …
Single-cell transcriptional diversity is a hallmark of developmental potential
GS Gulati, SS Sikandar, DJ Wesche, A Manjunath… - Science, 2020 - science.org
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …
differentiation trajectories. However, inferring both the state and direction of differentiation is …
Application of big data and machine learning in smart grid, and associated security concerns: A review
This paper conducts a comprehensive study on the application of big data and machine
learning in the electrical power grid introduced through the emergence of the next-generation …
learning in the electrical power grid introduced through the emergence of the next-generation …
NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer
SS Sikandar, KT Pate, S Anderson, D Dizon… - Cancer research, 2010 - AACR
NOTCH signaling is critical for specifying the intestinal epithelial cell lineage and for initiating
colorectal adenomas and colorectal cancers (CRC). Based on evidence that NOTCH is …
colorectal adenomas and colorectal cancers (CRC). Based on evidence that NOTCH is …
miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway
10.7554/eLife.01977.001 MicroRNAs (miRNAs) are important regulators of stem and
progenitor cell functions. We previously reported that miR-142 and miR-150 are upregulated in …
progenitor cell functions. We previously reported that miR-142 and miR-150 are upregulated in …
miR-23a Promotes the Transition from Indolent to Invasive Colorectal Cancer
…, D Dizon, NC Panarelli, JW Milsom, SS Sikandar… - Cancer discovery, 2012 - AACR
Colorectal cancer is a classic example of a tumor that progresses through multiple distinct
stages in its evolution. To understand the mechanisms regulating the transition from indolent …
stages in its evolution. To understand the mechanisms regulating the transition from indolent …
A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelia and oncogenesis
…, LJ Van Weele, S Cai, I Glykofridis, SS Sikandar… - Nature cell …, 2014 - nature.com
It has been postulated that there is a link between inflammation and cancer. Here we
describe a role for cell-intrinsic toll-like receptor-2 (TLR2; which is involved in inflammatory …
describe a role for cell-intrinsic toll-like receptor-2 (TLR2; which is involved in inflammatory …
[PDF][PDF] A quiescent Bcl11b high stem cell population is required for maintenance of the mammary gland
Stem cells in many tissues sustain themselves by entering a quiescent state to avoid genomic
insults and to prevent exhaustion caused by excessive proliferation. In the mammary gland…
insults and to prevent exhaustion caused by excessive proliferation. In the mammary gland…
[HTML][HTML] Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
… -11-1-0287, Department of Defense/Breast Cancer Research Program (BCRP) Innovator
Award W81XWH-13-1-0281, DoD Post-doctoral Fellowship W81XWH-12-1-0020 to SS We …
Award W81XWH-13-1-0281, DoD Post-doctoral Fellowship W81XWH-12-1-0020 to SS We …
Identification of a minority population of LMO2+ breast cancer cells that integrate into the vasculature and initiate metastasis
… SS and JA performed experiments and analyzed data with supervision from MFCGSG …
performed experiments and analyzed data during the revisions with supervision from SS and …
performed experiments and analyzed data during the revisions with supervision from SS and …