In the past century, gradual but sustained advances in our understanding of the molecular
mechanisms involved in the growth and invasive properties of cancer cells have led to better …

Prostatic development occurs as a result of an epithelial-mesenchymal interaction, which is
the basic developmental mechanism employed by all organs and organ systems composed …

This review on normal and neoplastic growth of the prostate emphasizes the importance of
epithelial–mesenchymal/stromal interactions. Accordingly, during prostatic development …

At least partial answers to these questions are now available. There are well-established
methods of identifying mutations, and there are known founder mutations that simplify testing in …

Cancer-associated fibroblasts (CAFs) are major components of the carcinoma microenvironment
that promote tumor progression. However, the mechanisms by which CAFs regulate …

… 1 , Jane Adams, Kim Boekelheide, L Earl Gray Jr, Simon W Hayward, Peter SJ Lees,
Barry S McIntyre, Kenneth M Portier, Teresa M Schnorr, Sherry G Selevan, John G …

This report describes the development and characterization of an epithelial cell line (BPH-1)
from human prostate tissue obtained by transurethral resection. Primary epithelial cell …

The human prostatic epithelial cell line BPH-1 is normally nontumorigenic in nude mice.
The present report demonstrates that this cell line can be permanently transformed by its …

Prostatic epithelium consists mainly of luminal and basal cells, which are presumed to
differentiate from common progenitor/stem cells. We hypothesize that progenitor/stem cells are …

Prostatic development is induced by androgens acting via mesenchymal–epithelial interactions.
Androgens elicit their morphogenetic effects by acting through androgen receptors (ARs…