Tankyrases 1 and 2 are central biotargets in the WNT/β-catenin signaling and Hippo
signaling pathways. We have previously developed tankyrase inhibitors bearing a 1,2,4-triazole …

Background: Chemo- and radiation therapy-based clinical management of different types of
cancers is associated with toxicity and several side effects. Therefore, there is always an …

Tankyrase 1 and 2 (TNKS1/2) catalyze post-translational modification by poly-ADP-ribosylation
of a plethora of target proteins. In this function, TNKS1/2 also impact the WNT/β-catenin …

The development of immune checkpoint inhibitors represents a major breakthrough in
cancer therapy. Nevertheless, a substantial number of patients fail to respond to checkpoint …

Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor
agents in selected tumor cell lines and mouse models. Here, we characterized the response …

Tankyrase 1 and 2 (TNKS1/2) catalyze post-translational modification by poly-ADP-ribosylation
of a plethora of target proteins. In this function, TNKS1/2 also impact the WNT/β-catenin …

The catalytic enzymes tankyrase 1 and 2 (TNKS1/2) poly-ADP-ribosylate target proteins,
including AXIN proteins, to earmark them for degradation by the ubiquitin-proteasomal system. …

The catalytic enzymes tankyrase 1 and 2 (TNKS1/2) alter protein turnover by poly-ADP-ribosylating
target proteins, which earmark them for degradation by the ubiquitin–proteasomal …

Plectasin is a 4.4-kDa antimicrobial peptide with the potential to be a treatment of infections
caused by gram-positive bacteria. Since plectasin is a large molecule compared to …

Background: Dysphagia is an alarm gastrointestinal symptom that may be a manifestation of
serious underlying condition, which necessitate proper and timely medical intervention. …