[HTML][HTML] Fibrosis: types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation
SA Antar, NA Ashour, ME Marawan… - International Journal of …, 2023 - mdpi.com
… The method is based on CTGF’s chaperone activity, which enhances TGF-β’s affinity for its
various receptors and results in stronger and longer-lasting responses. The TGF-β inducible …
various receptors and results in stronger and longer-lasting responses. The TGF-β inducible …
[HTML][HTML] Biomarkers in spinal cord injury: prognostic insights and future potentials
Spinal Cord Injury (SCI) is a major challenge in Neurotrauma research. Complex pathophysiological
processes take place immediately after the injury and later on as the chronic injury …
processes take place immediately after the injury and later on as the chronic injury …
Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti …
… β, PDGF, JNK, MCP1, α-SMA, and other growth factors, it has therapeutic efficacy in the
treatment of fibrotic diseases; (4) Anti-apoptotic effect through inhibition of caspase 3; (5) PFD ٬ s …
treatment of fibrotic diseases; (4) Anti-apoptotic effect through inhibition of caspase 3; (5) PFD ٬ s …
Uterine sarcoma: analysis of 13,089 cases based on surveillance, epidemiology, and end results database
Objective The aim was to study the incidence and survival of patients with uterine sarcoma
diagnosed in the period from 2000 to 2012 based on Surveillance, Epidemiology, and End …
diagnosed in the period from 2000 to 2012 based on Surveillance, Epidemiology, and End …
Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro …
… % arrest in the S phase of the cell cycle. However, 28.71% of untreated MCF-7 cells accumulated
in the S phase. Hence, compound 8e can cause arrest at the S phase of cell growth by …
in the S phase. Hence, compound 8e can cause arrest at the S phase of cell growth by …
Telmisartan attenuates diabetic nephropathy by mitigating oxidative stress and inflammation, and upregulating Nrf2/HO-1 signaling in diabetic rats
Diabetic nephropathy (DN) is a serious complication of diabetes and can lead to renal failure.
Telmisartan (TEL) is an approved angiotensin II type 1 receptor blocker for the treatment of …
Telmisartan (TEL) is an approved angiotensin II type 1 receptor blocker for the treatment of …
A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways
Aims The present study aimed to investigate the effect of nano selenium, sildenafil, and their
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …
Shark and ray faunas in the Middle and Late Eocene of the Fayum Area, Egypt
The Eocene rocks exposed in the Fayum Area, Egypt, are well known for their fossil vertebrates
but in recent times the sharks and rays have been largely neglected. Extensive surface …
but in recent times the sharks and rays have been largely neglected. Extensive surface …
Pirfenidone and vitamin D mitigate renal fibrosis induced by doxorubicin in mice with Ehrlich solid tumor
RM Hazem, SA Antar, YK Nafea, AA Al-Karmalawy… - Life Sciences, 2022 - Elsevier
Aims Doxorubicin is a prominent anticancer agent. However, its organotoxic potential has
restricted its clinical use. The current study was performed to investigate the protective effect of …
restricted its clinical use. The current study was performed to investigate the protective effect of …
[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …
a remarkable increase in its prevalence. This review article focuses on the definition of …