… mitochondrial degradation 72,73, or the lethal impact of ER-Golgi transport blockage as
one of the mechanisms explaining the demise of dopaminergic neurons during Parkinson’s …

… It should be noted that even in S. cerevisiae, the base has deubiquitination activity assigned
to Ubp6 [89]. In mammals this activity is probably shared by the ortholog of Ubp6, Usp14, …

… To extend our results and to examine the possible general role of p97/VCP in ERAD, we
turned to study the interaction of Cdc48p with ERAD substrates in the yeast S. cerevisiae, in …

… , and blotted between sheets of Whatman paper for 5 s under a pressure of about 1 kg, were
overlaid on top of the monolayer for 60 s. The nitrocellulose was then gently lifted from the …

… A pathology-focused approach in aging model organisms can yield new insights into the
primary mechanism(s) of aging and help understand how genes control lifespan. C. elegans …

Quality control mechanisms in the endoplasmic reticulum prevent deployment of aberrant or
unwanted proteins to distal destinations and target them to degradation by a process known …

… However, it is possible that in these cells calpain(s) is activated under the condition of
enhanced degradation, because most of the calpain(s) is believed to be in an inactive form in uiuo …

… sequence/phenobarbital induction) SHOSHANA BAR-NUN, GERT KREIBICH, MILTON
ADESNIK, … S and4 demonstrate that, whereas newly synthesized in vitro labeled albumin was re- …

… Biosynthetic Labeling and Cell Incubation—Cells were starved for methionine for 45 min
and either labeled for 45 min or pulse labeled for 15 min with [ 35 S]methionine (100 μCi/ml; …

Endoplasmic reticulum (ER)-associated degradation (ERAD) eliminates aberrant proteins
from the ER by dislocating them to the cytoplasm where they are tagged by ubiquitin and …