… In view of the important role of ZAP-70 in TCR signaling and its association with disease,
much attention has been devoted to ZAP-70’s structure and regulation. ZAP-70 and Syk are the …

Signaling by the epidermal growth factor receptor requires an allosteric interaction between
the kinase domains of two receptors, whereby one activates the other. We show that the …

Ca 2+ /calmodulin-dependent protein kinase-II (CaMKII) is unique among protein kinases for
its dodecameric assembly and its complex response to Ca 2+ . The crystal structure of the …

… 1A), which are found in all kingdoms of life, generating N-, O-, or S-glycosidic linkages at
the 1″ position of the nicotinamide ribose following a dissociative S N 2 reaction scheme. …

ZAP-70, a cytoplasmic tyrosine kinase required for T cell antigen receptor signaling, is
controlled by a regulatory segment that includes a tandem SH2 unit responsible for binding to …

ISWI-family enzymes remodel chromatin by sliding nucleosomes along DNA, but the
nucleosome translocation mechanism remains unclear. Here we use single-molecule FRET to …

… Ā/Ā cells when compared to ALC1+/+ (Figure S2S), suggesting that loss of PAR protection
… Cells lacking both ALC1 and HR also presented with a lower percentage of cells in S phase …

… SmFRET can alternatively be measured with surface-anchored molecules, which enables
the observation of conformational dynamics on a slower time scale of 100 ms–10 s, where …

… We repeated key experiments using mammalian enzyme from S. scrofa. Crystal structures for
… We expressed the S. scrofa γ isoform of CaMKII in Sf9 cells using a baculovirus expression …

Serial activation of the tyrosine kinases Lck and ZAP-70 initiates signaling downstream of
the T cell receptor. We previously reported the structure of an autoinhibited ZAP-70 variant in …