Robust neuronal dynamics in premotor cortex during motor planning

N Li, K Daie, K Svoboda, S Druckmann - Nature, 2016 - nature.com
… To accommodate the longer photoinhibition, we randomly varied the duration of the delay
epoch from 1.2 s to 1.7 s in 0.1-s increments. This resulted in photoinhibition that terminated at …

Ring attractor dynamics in the Drosophila central brain

SS Kim, H Rouault, S Druckmann, V Jayaraman - Science, 2017 - science.org
… To test whether the fly’s compass network enforces a unique bump within the EB, we took
advantage of the relative persistence of the visually evoked activity bump in darkness, and …

[HTML][HTML] A novel multiple objective optimization framework for constraining conductance-based neuron models by experimental data

S Druckmann, Y Banitt, AA Gidon… - Frontiers in …, 2007 - frontiersin.org
We present a novel framework for automatically constraining parameters of compartmental
models of neurons, given a large set of experimentally measured responses of these neurons…

Kilohertz frame-rate two-photon tomography

…, PE Deal, EW Miller, ER Schreiter, S Druckmann… - Nature …, 2019 - nature.com
… all scans using ScanImage’s waveform optimization feature to … data, we correct the
microscope’s projection function for the … These calibrations take less than 30 s and are performed …

[PDF][PDF] Reconstruction and simulation of neocortical microcircuitry

…, S Druckmann, R Dumusc, J Dynes, S Eilemann… - Cell, 2015 - cell.com
We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …

[HTML][HTML] A high-performance speech neuroprosthesis

…, F Kamdar, MF Glasser, LR Hochberg, S Druckmann… - Nature, 2023 - nature.com
… Our participant’s attempted speech was decoded at 62 words per minute, which is 3.4 times
as fast as the previous record 8 and begins to approach the speed of natural conversation (…

Maintenance of persistent activity in a frontal thalamocortical loop

ZV Guo, HK Inagaki, K Daie, S Druckmann, CR Gerfen… - Nature, 2017 - nature.com
… The delay epoch lasted for another 1.2 s after completion of pole retraction (1.3 s or 1.2 s
total). An auditory ‘go’ cue separated the delay and the response epochs (pure tone, 3.4 kHz, …

Angular velocity integration in a fly heading circuit

…, R Franconville, T Wolff, JD Seelig, S Druckmann… - Elife, 2017 - elifesciences.org
… Overall, we found P-EN neurons to be tuned to the fly’s heading as well as the fly’s rotations,
both when flies walked under visual closed loop conditions and in darkness (Figure 5—…

Separation of liposome-associated doxorubicin from non-liposome-associated doxorubicin in human plasma: implications for pharmacokinetic studies

S Druckmann, A Gabizon, Y Barenholz - Biochimica et Biophysica Acta …, 1989 - Elsevier
To characterize the pharmacokinetics of liposome-associated drugs, the fraction of drug
circulating in liposome-associated form and the absolute plasma drug levels must be determined…

Pharmacokinetic and imaging studies in patients receiving a formulation of liposome-associated adriamycin

A Gabizon, R Chisin, S Amselem, S Druckmann… - British Journal of …, 1991 - nature.com
Pharmacokinetic and imaging studies in 19 patients receiving liposome-entrapped adriamycin
(L-ADM) were carried out within the framework of a Phase I clinical trial (Gabizon et al., …