User profiles for S. Ecker

Simone Ecker

- Verified email at ucl.ac.uk - Cited by 2640

Sebastian Ecker

- Verified email at qtlabs.at - Cited by 801

Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens

S Knasmüller, W Parzefall, R Sanyal, S Ecker… - Mutation Research …, 1998 - Elsevier
The human hepatoma line (Hep G2) has retained the activities of various phase I and phase
II enzymes which play a crucial role in the activation/detoxification of genotoxic …

Epigenetic and transcriptional variability shape phenotypic plasticity

S Ecker, V Pancaldi, A Valencia, S Beck, DS Paul - BioEssays, 2018 - Wiley Online Library
Epigenetic and transcriptional variability contribute to the vast diversity of cellular and
organismal phenotypes and are key in human health and disease. In this review, we describe …

MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study

…, I Dilworth, J Dimopoulos, E Dörr, S Ecker… - The Lancet …, 2021 - thelancet.com
Background The concept of the use of MRI for image-guided adaptive brachytherapy (IGABT)
in locally advanced cervical cancer was introduced 20 years ago. Here, we report on …

[HTML][HTML] Genetic drivers of epigenetic and transcriptional variation in human immune cells

…, D Garrido-Martín, S Watt, Y Yan, K Kundu, S Ecker… - Cell, 2016 - cell.com
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia

…, P Papasaikas, P Jares, S Beŕ, D Rico, S Ecker… - Nature …, 2012 - nature.com
We have extensively characterized the DNA methylomes of 139 patients with chronic
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …

Noninvasive assessment of CO2-induced cerebral vasomotor response in normal individuals and patients with internal carotid artery occlusions.

EB Ringelstein, C Sievers, S Ecker, PA Schneider… - Stroke, 1988 - Am Heart Assoc
… All 55 patients with occlusion(s) were studied by CT imaging of the head to identify both
symptomatic and silent infarctions ipsilateral to the ICA occlusion(s). Territorial infarctions were …

Evidence-based dose planning aims and dose prescription in image-guided brachytherapy combined with radiochemotherapy in locally advanced cervical cancer

…, M Schmid, S Smet, H Westerveld, S Ecker… - Seminars in radiation …, 2020 - Elsevier
The last 2 decades have witnessed the development and broad adoption of image-guided
adaptive brachytherapy (IGABT) combined with radiochemotherapy in patients with locally …

Whole-genome fingerprint of the DNA methylome during human B cell differentiation

…, N Russińol, R Vilarrasa-Blasi, S Ecker… - Nature …, 2015 - nature.com
We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation
program by whole-genome bisulfite sequencing and high-density microarrays. We …

Development of the open‐source dose calculation and optimization toolkit matRad

…, H Gabrys, L Burigo, A Mairani, S Ecker… - Medical …, 2017 - Wiley Online Library
… For photons, we measure total run times of 145 s–1260 s for dose calculation and fluence
… For charged particles, we measure total run times of 63 s–993 s for dose calculation and …

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

…, A Martínez-Trillos, N Villamor, S Ecker… - Genome …, 2014 - genome.cshlp.org
Chronic lymphocytic leukemia (CLL) has heterogeneous clinical and biological behavior.
Whole-genome and -exome sequencing has contributed to the characterization of the …