Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens
S Knasmüller, W Parzefall, R Sanyal, S Ecker… - Mutation Research …, 1998 - Elsevier
The human hepatoma line (Hep G2) has retained the activities of various phase I and phase
II enzymes which play a crucial role in the activation/detoxification of genotoxic …
II enzymes which play a crucial role in the activation/detoxification of genotoxic …
Epigenetic and transcriptional variability shape phenotypic plasticity
Epigenetic and transcriptional variability contribute to the vast diversity of cellular and
organismal phenotypes and are key in human health and disease. In this review, we describe …
organismal phenotypes and are key in human health and disease. In this review, we describe …
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study
…, I Dilworth, J Dimopoulos, E Dörr, S Ecker… - The Lancet …, 2021 - thelancet.com
Background The concept of the use of MRI for image-guided adaptive brachytherapy (IGABT)
in locally advanced cervical cancer was introduced 20 years ago. Here, we report on …
in locally advanced cervical cancer was introduced 20 years ago. Here, we report on …
[HTML][HTML] Genetic drivers of epigenetic and transcriptional variation in human immune cells
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…
phenotypes is a major challenge in human genetics and medicine. We carried out high-…
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
We have extensively characterized the DNA methylomes of 139 patients with chronic
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …
Noninvasive assessment of CO2-induced cerebral vasomotor response in normal individuals and patients with internal carotid artery occlusions.
EB Ringelstein, C Sievers, S Ecker, PA Schneider… - Stroke, 1988 - Am Heart Assoc
… All 55 patients with occlusion(s) were studied by CT imaging of the head to identify both
symptomatic and silent infarctions ipsilateral to the ICA occlusion(s). Territorial infarctions were …
symptomatic and silent infarctions ipsilateral to the ICA occlusion(s). Territorial infarctions were …
Evidence-based dose planning aims and dose prescription in image-guided brachytherapy combined with radiochemotherapy in locally advanced cervical cancer
…, M Schmid, S Smet, H Westerveld, S Ecker… - Seminars in radiation …, 2020 - Elsevier
The last 2 decades have witnessed the development and broad adoption of image-guided
adaptive brachytherapy (IGABT) combined with radiochemotherapy in patients with locally …
adaptive brachytherapy (IGABT) combined with radiochemotherapy in patients with locally …
Whole-genome fingerprint of the DNA methylome during human B cell differentiation
…, N Russińol, R Vilarrasa-Blasi, S Ecker… - Nature …, 2015 - nature.com
We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation
program by whole-genome bisulfite sequencing and high-density microarrays. We …
program by whole-genome bisulfite sequencing and high-density microarrays. We …
Development of the open‐source dose calculation and optimization toolkit matRad
… For photons, we measure total run times of 145 s–1260 s for dose calculation and fluence
… For charged particles, we measure total run times of 63 s–993 s for dose calculation and …
… For charged particles, we measure total run times of 63 s–993 s for dose calculation and …
Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia
…, A Martínez-Trillos, N Villamor, S Ecker… - Genome …, 2014 - genome.cshlp.org
Chronic lymphocytic leukemia (CLL) has heterogeneous clinical and biological behavior.
Whole-genome and -exome sequencing has contributed to the characterization of the …
Whole-genome and -exome sequencing has contributed to the characterization of the …