User profiles for S. Elderkin
 | Sarah ElderkinTenure Track Group Leader Babraham Institute UK Verified email at babraham.ac.uk Cited by 3255 |
[HTML][HTML] RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3
Polycomb-repressive complex 1 (PRC1) has a central role in the regulation of heritable gene
silencing during differentiation and development. PRC1 recruitment is generally attributed …
silencing during differentiation and development. PRC1 recruitment is generally attributed …
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements
…, S Elderkin, K Tabbada, E Darbo, S Andrews… - Genome …, 2015 - genome.cshlp.org
The mammalian genome harbors up to one million regulatory elements often located at
great distances from their target genes. Long-range elements control genes through physical …
great distances from their target genes. Long-range elements control genes through physical …
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome
The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC)
pluripotency by silencing lineage-specifying developmental regulator genes 1 . Emerging …
pluripotency by silencing lineage-specifying developmental regulator genes 1 . Emerging …
[HTML][HTML] Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment
…, J Sharif, NP Blackledge, V De Marco, S Elderkin… - Cell reports, 2014 - cell.com
The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2
are recruited to target sites in vertebrate cells are not well understood. Building on recent …
are recruited to target sites in vertebrate cells are not well understood. Building on recent …
Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells
…, D Hussein, Y Wang, S Elderkin… - Journal of cell …, 2001 - journals.biologists.com
BUB1 is a budding yeast gene required to ensure that progression through mitosis is coupled
to correct spindle assembly. Two related human protein kinases, Bub1 and BubR1, both …
to correct spindle assembly. Two related human protein kinases, Bub1 and BubR1, both …
Ubiquitin‐specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor
GN Maertens, S El Messaoudi‐Aubert, S Elderkin… - The EMBO …, 2010 - embopress.org
… Note that our baculovirus constructs encode the mouse homologues of the Psc and Sce
proteins, but the findings were confirmed using 35 S-labelled versions of human CBX8, BMI1, …
proteins, but the findings were confirmed using 35 S-labelled versions of human CBX8, BMI1, …
[HTML][HTML] A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin
S Elderkin, GN Maertens, M Endoh, DL Mallery… - Molecular cell, 2007 - cell.com
Recent studies have shown that PRC1-like Polycomb repressor complexes monoubiquitylate
chromatin on histone H2A at lysine residue 119. Here we have analyzed the function of the …
chromatin on histone H2A at lysine residue 119. Here we have analyzed the function of the …
Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP–aluminum fluoride: insights into activator mechanochemical action
…, J Schumacher, S Jones, S Elderkin… - Genes & …, 2001 - genesdev.cshlp.org
Conformational changes in sigma 54 (ς 54 ) and ς 54 -holoenzyme depend on nucleotide
hydrolysis by an activator. We now show that ς 54 and its holoenzyme bind to the central ATP-…
hydrolysis by an activator. We now show that ς 54 and its holoenzyme bind to the central ATP-…
[HTML][HTML] Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression
… Enrichment of KEGG pathways was assessed by Fisher’s exact test in R Stats package,
and P values were adjusted for multiple testing by calculating false discovery rates. …
and P values were adjusted for multiple testing by calculating false discovery rates. …
Mechanism of action of the Escherichia coli phage shock protein PspA in repression of the AAA family transcription factor PspF
S Elderkin, S Jones, J Schumacher… - Journal of molecular …, 2002 - Elsevier
… The open complex assay involves σ 54 RNA holoenzyme bound to an 88 bp homoduplex
S. meliloti nifH promoter DNA fragment (see Materials and Methods) as a closed complex, …
S. meliloti nifH promoter DNA fragment (see Materials and Methods) as a closed complex, …