Pharmacokinetics/pharmacodynamics and the stages of drug development: role of modeling and simulation
… PK/PDbased M&S before clinical development is highly dependent on the amount and quality
of information available from preclinical studies and literature data on clinical comparator(s…
of information available from preclinical studies and literature data on clinical comparator(s…
[HTML][HTML] Towards complete and error-free genome assemblies of all vertebrate species
High-quality and complete reference genome assemblies are fundamental for the application
of genomics to biology, disease, and biodiversity conservation. However, such assemblies …
of genomics to biology, disease, and biodiversity conservation. However, such assemblies …
Time discounting and time preference: A critical review
S Frederick, G Loewenstein… - Journal of economic …, 2002 - aeaweb.org
… about one’s future welfare to a degree that exceeds the degree of psychological connectedness
that obtains between one’s current self and one’s future self. Frederick, Loewenstein, …
that obtains between one’s current self and one’s future self. Frederick, Loewenstein, …
The eROSITA X-ray telescope on SRG
…, M Freyberg, P Friedrich, S Friedrich… - Astronomy & …, 2021 - aanda.org
… A hexapod structure forms the mechanical interface to the S/C … They belong to the attitude
system of the S/C but serve also … ~ 100 s at the ecliptic equator to more than 10 000 s close to …
system of the S/C but serve also … ~ 100 s at the ecliptic equator to more than 10 000 s close to …
Post-prandial decrease of circulating human ghrelin levels
M Tschöp, R Wawarta, RL Riepl, S Friedrich… - Journal of …, 2001 - Springer
Ghrelin, an endogenous ligand of the GH secretagogue-receptor, has recently been shown
to stimulate GH secretion and to have orexigenic and adipogenic effects in rodents, but little …
to stimulate GH secretion and to have orexigenic and adipogenic effects in rodents, but little …
Neutral, single-component nickel (II) polyolefin catalysts that tolerate heteroatoms
TR Younkin, EF Connor, JI Henderson, SK Friedrich… - Science, 2000 - science.org
… Both traditional catalysts for Ziegler-Natta polymerization and cationic metallocenes suffer
because heteroatoms (such as O, N, and S) poison the catalysts and cocatalysts [such as …
because heteroatoms (such as O, N, and S) poison the catalysts and cocatalysts [such as …
A comprehensive comparative review of sequence-based predictors of DNA-and RNA-binding residues
J Yan, S Friedrich, L Kurgan - Briefings in bioinformatics, 2016 - academic.oup.com
… S e n s i t i v i t y = T P T P + F N S p e c i f i c i t y = T N F P + T N … complete the prediction of
DNA-, RNA-binding residues for an average-sized protein with about 200 amino acids in <1 s. …
DNA-, RNA-binding residues for an average-sized protein with about 200 amino acids in <1 s. …
[PDF][PDF] Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis
G Millonig, FM Reimann, S Friedrich, H Fonouni… - …, 2008 - Wiley Online Library
… , the decrease of liver stiffness highly correlated with decreasing bilirubin (Spearman’s … In
addition, the patient’s medical history showed continuous alcohol abuse in the last 2 decades …
addition, the patient’s medical history showed continuous alcohol abuse in the last 2 decades …
[HTML][HTML] The eROSITA Final Equatorial Depth Survey (eFEDS)-X-ray catalogue
Context. The eROSITA X-ray telescope on board the Spectrum-Poentgen-Gamma (SPG)
observatory combines a large field of view and a large collecting area in the energy range …
observatory combines a large field of view and a large collecting area in the energy range …
Neutral nickel (II)-based catalysts for ethylene polymerization
C Wang, S Friedrich, TR Younkin, RT Li… - …, 1998 - ACS Publications
Neutral salicylaldiminato Ni(II) complexes have been synthesized, and their structure has
been confirmed by an X-ray analysis of complex 4e. These compounds are active catalysts for …
been confirmed by an X-ray analysis of complex 4e. These compounds are active catalysts for …