[HTML][HTML] The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a
collaborative network of researchers working together on a range of large-scale studies that …
collaborative network of researchers working together on a range of large-scale studies that …
[HTML][HTML] Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
… We used within-sibship models which use deviations of the individual’s genotype from the …
genotype is 1.5 risk alleles and the individual’s deviations are +0.5 and −0.5, respectively. The …
genotype is 1.5 risk alleles and the individual’s deviations are +0.5 and −0.5, respectively. The …
Common genetic variants influence human subcortical brain structures
…, G Cuellar-Partida, A Den Braber, S Giddaluru… - Nature, 2015 - nature.com
The highly complex structure of the human brain is strongly shaped by genetic influences 1 .
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …
[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
…, T Espeseth, S Giakoumaki, S Giddaluru… - Nature …, 2018 - nature.com
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …
with many important life outcomes. We combine cognitive and genetic data from the …
The genetic architecture of the human cerebral cortex
…, JM Ford, M Fukunaga, ME Garrett, T Ge, S Giddaluru… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological, …
Variations in human cortical surface area and thickness are associated with neurological, …
[HTML][HTML] Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N= 53 949)
…, JC Bis, J Bressler, V Chouraki, S Giddaluru… - Molecular …, 2015 - nature.com
General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this important, …
adolescence to old age. We investigated the genetic contribution to variation in this important, …
[HTML][HTML] Novel genetic loci associated with hippocampal volume
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …
Novel genetic loci underlying human intracranial volume identified through genome-wide association
Intracranial volume reflects the maximally attained brain size during development, and remains
stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain …
stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain …
Genetic architecture of subcortical brain structures in 38,851 individuals
…, S Lovestone, S Giddaluru, S Le Hellard… - Nature …, 2019 - nature.com
Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens, …
We identified common genetic variation related to the volumes of the nucleus accumbens, …
Within-sibship GWAS improve estimates of direct genetic effects
…, DR Dokuru, LM Evans, EJC de Geus, S Giddaluru… - BioRxiv, 2021 - biorxiv.org
… associations using the individual’s raw genotypes and population-based samples of unrelated
individuals, uses deviations of the individual’s genotype from the mean genotype within …
individuals, uses deviations of the individual’s genotype from the mean genotype within …