[HTML][HTML] The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

…, T Frodl, V Frouin, H Garavan, S Giddaluru… - Brain imaging and …, 2014 - Springer
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a
collaborative network of researchers working together on a range of large-scale studies that …

[HTML][HTML] Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

…, DR Dokuru, LM Evans, EJC de Geus, S Giddaluru… - Nature …, 2022 - nature.com
… We used within-sibship models which use deviations of the individual’s genotype from the …
genotype is 1.5 risk alleles and the individual’s deviations are +0.5 and −0.5, respectively. The …

Common genetic variants influence human subcortical brain structures

…, G Cuellar-Partida, A Den Braber, S Giddaluru… - Nature, 2015 - nature.com
The highly complex structure of the human brain is strongly shaped by genetic influences 1 .
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …

[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

…, T Espeseth, S Giakoumaki, S Giddaluru… - Nature …, 2018 - nature.com
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

The genetic architecture of the human cerebral cortex

…, JM Ford, M Fukunaga, ME Garrett, T Ge, S Giddaluru… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological, …

[HTML][HTML] Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N= 53 949)

…, JC Bis, J Bressler, V Chouraki, S Giddaluru… - Molecular …, 2015 - nature.com
General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this important, …

[HTML][HTML] Novel genetic loci associated with hippocampal volume

…, A Den Braber, NT Doan, S Ehrlich, S Giddaluru… - Nature …, 2017 - nature.com
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …

Novel genetic loci underlying human intracranial volume identified through genome-wide association

…, NT Doan, S Ehrlich, I Filippi, T Ge, S Giddaluru… - Nature …, 2016 - nature.com
Intracranial volume reflects the maximally attained brain size during development, and remains
stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain …

Genetic architecture of subcortical brain structures in 38,851 individuals

…, S Lovestone, S Giddaluru, S Le Hellard… - Nature …, 2019 - nature.com
Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens, …

Within-sibship GWAS improve estimates of direct genetic effects

…, DR Dokuru, LM Evans, EJC de Geus, S Giddaluru… - BioRxiv, 2021 - biorxiv.org
… associations using the individual’s raw genotypes and population-based samples of unrelated
individuals, uses deviations of the individual’s genotype from the mean genotype within …