[PDF][PDF] The assembly pathway of mitochondrial respiratory chain complex I
S Guerrero-Castillo, F Baertling, D Kownatzki… - Cell metabolism, 2017 - cell.com
… Guerrero-Castillo et al. use a dynamic complexome profiling approach delineating the
stepwise incorporation of all but one subunit into complex I and the involvement of all known and …
stepwise incorporation of all but one subunit into complex I and the involvement of all known and …
[PDF][PDF] The m-AAA protease associated with neurodegeneration limits MCU activity in mitochondria
…, M Patron, M Mühlmeister, S Guerrero-Castillo… - Molecular cell, 2016 - cell.com
… We conclude that mature EMRE is localized in a protease-protected location in the IM, while
the precursor form of EMRE remains protease-accessible in the IMS, indicating incomplete …
the precursor form of EMRE remains protease-accessible in the IMS, indicating incomplete …
[HTML][HTML] Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex
…, M Mühlmeister, K Gotthardt, S Guerrero-Castillo… - … et Biophysica Acta (BBA …, 2016 - Elsevier
We have analyzed the distribution of mitochondrial contact site and cristae organizing system
(MICOS) complex proteins and mitochondrial intermembrane space bridging complex (MIB…
(MICOS) complex proteins and mitochondrial intermembrane space bridging complex (MIB…
[HTML][HTML] A salvage pathway maintains highly functional respiratory complex I
…, H Giese, K Zwicker, S Guerrero-Castillo… - Nature …, 2020 - nature.com
… Here, we report that the NADH-oxidizing N-module of CI is turned over at a higher rate
and largely independently of the rest of the complex by mitochondrial matrix protease ClpXP, …
and largely independently of the rest of the complex by mitochondrial matrix protease ClpXP, …
[HTML][HTML] Unraveling the complexity of mitochondrial complex I assembly: A dynamic process
L Sánchez-Caballero, S Guerrero-Castillo… - Biochimica et Biophysica …, 2016 - Elsevier
Mammalian complex I is composed of 44 different subunits and its assembly requires at least
13 specific assembly factors. Proper function of the mitochondrial respiratory chain enzyme …
13 specific assembly factors. Proper function of the mitochondrial respiratory chain enzyme …
[PDF][PDF] MR-1S interacts with PET100 and PET117 in module-based assembly of human cytochrome c oxidase
S Vidoni, ME Harbour, S Guerrero-Castillo, A Signes… - Cell reports, 2017 - cell.com
The biogenesis of human cytochrome c oxidase (COX) is an intricate process in which three
mitochondrial DNA (mtDNA)-encoded core subunits are assembled in a coordinated way …
mitochondrial DNA (mtDNA)-encoded core subunits are assembled in a coordinated way …
[PDF][PDF] Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa
…, T Gardeitchik, M Mohamed, S Guerrero-Castillo… - The American Journal of …, 2017 - cell.com
Defects of the V-type proton (H + ) ATPase (V-ATPase) impair acidification and intracellular
trafficking of membrane-enclosed compartments, including secretory granules, endosomes, …
trafficking of membrane-enclosed compartments, including secretory granules, endosomes, …
[HTML][HTML] Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
…, K Siegmund, K Zwicker, S Guerrero-Castillo… - Nature …, 2018 - nature.com
… We conclude that movement of loop TMH1-2 ND3 located at the ubiquinone-binding pocket
is … We conclude that movement of loop TMH1-2 ND3 is required to drive the proton pumps of …
is … We conclude that movement of loop TMH1-2 ND3 is required to drive the proton pumps of …
Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I
…, J Warnau, S Guerrero-Castillo… - Proceedings of the …, 2015 - National Acad Sciences
Mitochondrial proton-pumping NADH:ubiquinone oxidoreductase (respiratory complex I)
comprises more than 40 polypeptides and contains eight canonical FeS clusters. The …
comprises more than 40 polypeptides and contains eight canonical FeS clusters. The …
[PDF][PDF] Bi-allelic mutations in the mitochondrial ribosomal protein MRPS2 cause sensorineural hearing loss, hypoglycemia, and multiple OXPHOS complex …
…, B Ruzzenente, D Karall, S Guerrero-Castillo… - The American Journal of …, 2018 - cell.com
… This extended range of interactors suggests that MRPS2 has adopted a primarily structural
role, which is consistent with our findings that its loss is associated with impaired mt-SSU …
role, which is consistent with our findings that its loss is associated with impaired mt-SSU …