Background Insulin resistance is a critical cause of metabolic dysfunctions. Metabolic
dysfunction is common in patients with cancer and is associated with higher cancer recurrence …

There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk
and function as molecular effectors of physical activity. Although past studies have focused …

Reactive oxygen species (ROS) act as intracellular compartmentalized second messengers,
mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested …

Metabolic dysfunction is a comorbidity of many types of cancers. Disruption of glucose
metabolism is of concern, as it is associated with higher cancer recurrence rates and reduced …

Exercise training is a powerful means to combat metabolic diseases. Mice are extensively
used to investigate the benefits of exercise, but mild cold stress induced by ambient housing …

Obesity and type 2 diabetes (T2D) are growing health challenges with unmet treatment needs.
Traf2- and NCK-interacting protein kinase (TNIK) is a recently identified obesity- and T2D-…

Objective Reactive oxygen species (ROS) have been proposed as signaling molecules
mediating exercise training adaptation, but the ROS source has remained unclear. This study …

The molecular events governing skeletal muscle glucose uptake have pharmacological
potential for managing insulin resistance in conditions such as obesity, diabetes, and cancer. …

Rac1 muscle knockout exacerbates the detrimental effect of high‐fat diet on insulin‐stimulated
muscle glucose uptake independently of Akt - Raun - 2018 - The Journal of Physiology - …

The production of reactive oxygen species (ROS) by NADPH oxidase (NOX) 2 has been linked
to both insulin resistance and exercise training adaptations in skeletal muscle. This study …