Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a …

… To estimate the values of S i,g,s … S i,s the probability for an individual of sex s of surviving
over the age category i that spans from age t 1 to age t 2 , then we can derive S i,g,s from S i,s …

We conducted a search for rare, functional variants altering susceptibility to Alzheimer's
disease that exploited knowledge of common variants associated with the same disease. We …

Mild cognitive impairment (MCI) is considered as a transition phase between normal aging
and Alzheimer's disease (AD). MCI confers an increased risk of developing AD, although the …

Objective: To assess the relationship between Alzheimer disease (AD)–related pathologic
changes in frontal cortical brain biopsy and AD biomarkers in ventricular vs lumbar CSF, and …

The Alzheimer’s Disease Sequencing Project (ADSP) undertook whole exome sequencing
in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls …

… controlled trials: Souvenir I (225 drug-naive patients with mild Alzheimer's disease
dementia), Souvenir II (259 drug-naive patients with mild Alzheimer's disease dementia), and S-…

… Individual sessions included tailoring of the participant’s diet. Group sessions provided
discussions and practical exercises for facilitating lifestyle changes. The physical exercise …

An increased frequency of apolipoprotein E E4 allele has been reported in patients with late
onset Alzheimer's disease. Apolipoprotein E participates in the transport of cholesterol and …