Genetic correlations of polygenic disease traits: from theory to practice
The genetic correlation describes the genetic relationship between two traits and can
contribute to a better understanding of the shared biological pathways and/or the causality …
contribute to a better understanding of the shared biological pathways and/or the causality …
[PDF][PDF] GCTA: a tool for genome-wide complex trait analysis
For most human complex diseases and traits, SNPs identified by genome-wide association
studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly …
studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly …
[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …
become more accurate as training sample sizes increase. The standard approach for …
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …
variation is unique to individual disorders or shared across disorders is unclear. To examine …
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
…, JA Knowles, B Konte, C Laurent, P Lee, SH Lee… - Nature …, 2017 - nature.com
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …
[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
…, S Godard, JI Goldstein, V Golimbet, S Gopal… - The American Journal of …, 2014 - cell.com
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
Schizophrenia is a complex disorder caused by both genetic and environmental factors.
Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the …
Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the …
[HTML][HTML] Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture
The direct estimation of heritability from genome-wide common variant data as implemented
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …
RICOPILI: rapid imputation for COnsortias PIpeLIne
Genome-wide association study (GWAS) analyses, at sufficient sample sizes and power,
have successfully revealed biological insights for several complex traits. RICOPILI, an open-…
have successfully revealed biological insights for several complex traits. RICOPILI, an open-…
Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome‐wide association study of both common and …
Attention‐deficit hyperactivity disorder (ADHD) is a complex polygenic disorder. This study
aimed to discover common and rare DNA variants associated with ADHD in a large …
aimed to discover common and rare DNA variants associated with ADHD in a large …