Mass spectrometry imaging (MSI) is an emerging technology in cancer metabolomics.
Desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization (MALDI) …

The Signal Transducer and Activator of Transcription (STAT)3 and 5 proteins are activated
by many cytokine receptors to regulate specific gene expression and mitochondrial functions. …

We show that the antidiabetic drug metformin inhibits the expression of genes coding for
multiple inflammatory cytokines seen during cellular senescence. Conditioned medium ( CM ) …

Constitutive activation of growth factor signaling pathways paradoxically triggers a cell cycle
arrest known as cellular senescence. In primary cells expressing oncogenic ras, this …

… P value as indicated, two-sided Student’s t-test. g,h, Fluorescence in situ hybridization (FISH)
with an antisense or sense probe overlapping the 5.8S (5′) rRNA processing site 2 as …

… Igelmann et al. identified a hydride transfer complex (HTC) that drives metabolic … Two-tailed
Student’st test (A) or ANOVA (B and D–F) with Šıdá k’s multiple comparisons test …

… quantification with 50 cycles of 95C 20 s, 58C 20 s, 72C 30 s, melting curve (95C for 60 s,
40C for 5 s, 65C for 1 s up to 98C by ramping at 0.07C/s). Analysis was done using LightCycler …

Most cancers arise in old individuals, which also accumulate senescent cells. Cellular
senescence can be experimentally induced by expression of oncogenes or telomere shortening …

… Mutation in the YEATS domain of ENL (Eleven-Nineteen Leukemia) in Wilm’s tumors
enhances the ability of this protein to seed biomolecular condensates at the loci with acetylated …

Pancreatic adenocarcinomas (PDAC) often possess mutations in K-Ras that stimulate the
ERK pathway. Aberrantly high ERK activation triggers oncogene-induced senescence, which …