SARS-CoV-2, the virus underlying COVID-19, has now been recognized to cause multiorgan
disease with a systemic effect on the host. To effectively combat SARS-CoV-2 and the …

Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of
patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell …

Therapeutic applications of nuclease-based genome editing would benefit from improved
methods for transgene integration via homology-directed repair (HDR). To improve HDR …

Although COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis
remains unclear. Exposure of human iPSC-derived heart cells to SARS-CoV-2 revealed …

SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to
its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover …

Although SARS-CoV-2, the causative virus of the global COVID-19 pandemic, primarily affects
the respiratory tract, it is now recognized to have broad multi-organ tropism and systemic …

Elastic-and inelastic-scattering cross sections for low-energy electrons in Hg have been
obtained through comparison of experimental and calculated transport data. Electron-electron …

SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to
its cellsurface receptor ACE2. We conducted an unbiased CRISPRi screen to uncover …

Cell-derived matrices (CDMs) isolated from cultured cells provide complex and tissue-specific
biochemical and physical cues derived from the extracellular matrix (ECM) that are lacking …

Aims frailty is proposed as a summative measure of health status and marker of individual
vulnerability. We aimed to investigate the discriminative capacity of a frailty index (FI) derived …