User profiles for S. Knott

Simon Knott

Research Scientist, Cedars-Sinai Medical Center
Verified email at cshl.edu
Cited by 3386

A simple regression method for mapping quantitative trait loci in line crosses using flanking markers

CS Haley, SA Knott - Heredity, 1992 - nature.com
The use of flanking marker methods has proved to be a powerful tool for the mapping of
quantitative trait loci (QTL) in the segregating generations derived from crosses between inbred …

Kinematics of the western Mediterranean

JF Dewey, ML Helman, SD Knott, E Turco… - Geological Society …, 1989 - lyellcollection.org
… In a general sense, the age of basins and mountains is greatest to the N and W and decreases
to the S and E. This pattern of ages is clearly related to the evolution of the region (see …

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

…, C Hayward, NK Gray, J Floyd, CNA Palmer, SA Knott… - Nature …, 2008 - nature.com
… After initial denaturation at 96 C for 6 min, DNA was amplified with 35 cycles of 94 C for 30
s, 55 C for 30 s and 72 C for 1 min, followed by a final extension at 72 C for 10 min. All PCR …

Genetic mapping of quantitative trait loci for growth and fatness in pigs

L Andersson, CS Haley, H Ellegren, SA Knott… - Science, 1994 - science.org
The European wild boar was crossed with the domesticated Large White pig to genetically
dissect phenotypic differences between these populations for growth and fat deposition. The …

Mapping quantitative trait loci in crosses between outbred lines using least squares.

CS Haley, SA Knott, JM Elsen - Genetics, 1994 - academic.oup.com
The use of genetic maps based upon molecular markers has allowed the dissection of some
of the factors underlying quantitative variation in crosses between inbred lines. For many …

QTL Express: mapping quantitative trait loci in simple and complex pedigrees

G Seaton, CS Haley, SA Knott, M Kearsey… - …, 2002 - academic.oup.com
QTL Express is the first application for Quantitative Trait Locus (QTL) mapping in outbred
populations with a web-based user interface. User input of three files containing a marker map, …

Methods for multiple-marker mapping of quantitative trait loci in half-sib populations

SA Knott, JM Elsen, CS Haley - Theoretical and applied genetics, 1996 - Springer
In this paper we consider the detection of individual loci controlling quantitative traits of interest
(quantitative trait loci or QTLs) in the large half-sib family structure found in some species. …

Asparagine bioavailability governs metastasis in a model of breast cancer

SRV Knott, E Wagenblast, S Khan, SY Kim, M Soto… - Nature, 2018 - nature.com
Using a functional model of breast cancer heterogeneity, we previously showed that clonal
sub-populations proficient at generating circulating tumour cells were not all equally capable …

[PDF][PDF] Translocation of viable gut microbiota to mesenteric adipose drives formation of creeping fat in humans

…, SJH Sui, S Yang, D Underhill, MJ Brady, S Knott… - Cell, 2020 - cell.com
… innocuum’s ability to translocate to the MAT was confirmed prospectively in gnotobiotic mice
gavaged with a CrF-derived strain of C. innocuum, resulting in MAT expansion and recovery …

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

…, CM Perou, JE Wilkinson, GJ Hannon, SRV Knott - Nature, 2015 - nature.com
… After the transfection mixture was added to the HBS, vigorous bubbling continued for 30–60
s. After letting the resultant mixture stand for 15 min, it was added to the packaging cells …