Genome dynamics are intimately linked to the regulation of gene expression, the most
fundamental mechanism in biology, yet we still do not know whether the very process of …

… This study was undertaken to characterize at the molecular level the signaling pathway(s)
promoting HO-1 upregulation by hypericin-mediated PDT, with particular emphasis on the …

Photodynamic therapy (PDT) is an anticancer approach utilizing a light-absorbing molecule
and visible light irradiation to generate, in the presence of O 2, cytotoxic reactive oxygen …

Background The estrogen receptor alpha (ERα) is found predominately in the nucleus, both
in hormone stimulated and untreated cells. Intracellular distribution of the ERα changes in …

… ) should co-localise at just one nuclear site, rather than each gene localizing at any of the
many other ERα sites or splicing factor enriched speckles, perhaps with any of the other 100 s …

… All cell lines were maintained in Dulbecco’s modified Eagle’s medium (DMEM) with … V
program X-013 according to the manufacturer’s protocol. MDA-MB231 cells were mock-transfected …

… at 98 C for 30 s followed by 35 cycles of 98 C for 10 s and 72 C for 75 s. Sequence the
products to identify the insertion sites. In the case of the insertions described in Germier et al. …

… Imaging transcription bursts over two-hour windows, we measure an average bursting time
of ~200 s and an average time between bursts of ~630 s. As a population, the observed cells …

… Amplification conditions: 1 min at 50C, 3 min at 95C followed by 40 cycles (20 s at 95C, 20
s at 60C, 20 s at 72C). mRNA expression were normalized against expression levels of the …

… The transcription factor E2F1 is known to promote G1–S cell cycle transition and S phase
progression (28), and thus, cPGI 2 may be inducing S phase gene expression, including DNA …