User profiles for S. Kohtala

Samuel Kohtala

- Verified email at helsinki.fi - Cited by 394

Sampsa Kohtala

- Verified email at ntnu.no - Cited by 107

[HTML][HTML] Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms

S Kohtala - Pharmacological Reports, 2021 - Springer
… mimicking certain aspects of ketamine’s action, have risen out of … molecular complexities of
ketamine’s action, both basic and … understanding of ketamine’s effects in treating depression. …

[HTML][HTML] Time is of the essence: coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine

S Kohtala, O Alitalo, M Rosenholm, S Rozov… - Pharmacology & …, 2021 - Elsevier
Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating
depression and suicidal ideation. Intense research efforts have been undertaken to expose the …

Encoding, consolidation, and renormalization in depression: synaptic homeostasis, plasticity, and sleep integrate rapid antidepressant effects

T Rantamäki, S Kohtala - Pharmacological reviews, 2020 - ASPET
Recent studies have strived to find an association between rapid antidepressant effects and
a specific subset of pharmacological targets and molecular pathways. Here, we propose a …

[HTML][HTML] Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

…, D Popova, P Sipilä, R Guirado, S Kohtala… - Scientific reports, 2017 - nature.com
… For statistical analysis two-sided tests including unpaired two-tailed Student’s t-test, Mann
… , Pearson’s χ 2 test and Spearman’s correlation test were used. Levene’s test was used to …

[HTML][HTML] Detecting glass and metal in consumer trash bags during waste collection using convolutional neural networks

OI Funch, R Marhaug, S Kohtala, M Steinert - Waste management, 2021 - Elsevier
We present a proof-of-concept method to classify the presence of glass and metal in
consumer trash bags. With the prevalent utilization of waste collection trucks in municipal solid …

[HTML][HTML] Cortical excitability and activation of TrkB signaling during rebound slow oscillations are critical for rapid antidepressant responses

S Kohtala, W Theilmann, M Rosenholm, L Penna… - Molecular …, 2019 - Springer
… pharmacological basis governing ketamine’s antidepressant effects. Experimental evidence
… ketamine’s therapeutic effects [12], also contributes to the enhanced AMPA-R function [13]. …

Brief isoflurane anesthesia produces prominent phosphoproteomic changes in the adult mouse hippocampus

S Kohtala, W Theilmann, T Suomi… - ACS chemical …, 2016 - ACS Publications
Anesthetics are widely used in medical practice and experimental research, yet the
neurobiological basis governing their effects remains obscure. We have here used quantitative …

[HTML][HTML] Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine …

S Kohtala, W Theilmann, M Rosenholm, HK Müller… - …, 2019 - Elsevier
Subanesthetic rather than anesthetic doses are thought to bring the rapid antidepressant
effects of the NMDAR (N-methyl-d-aspartate receptor) antagonist ketamine. Among molecular …

[HTML][HTML] Ketamine reduces electrophysiological network activity in cortical neuron cultures already at sub-micromolar concentrations–Impact on TrkB-ERK1/2 signaling

A Ahtiainen, I Annala, M Rosenholm, S Kohtala… - …, 2023 - Elsevier
The dissociative anesthetic ketamine regulates cortical activity in a dose-dependent manner.
Subanesthetic-dose ketamine has paradoxical excitatory effects which is proposed to …

Virtually hosted hackathons for design research: lessons learned from the international design engineering annual (IDEA) challenge 2021

…, RM Real, C Cox, N Horvat, S Kohtala… - Proceedings of the …, 2022 - cambridge.org
This paper provides an overview and appraisal of the International Design Engineering
Annual (IDEA) challenge - a virtually hosted design hackathon run with the aim of generating a …