[HTML][HTML] Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms
S Kohtala - Pharmacological Reports, 2021 - Springer
… mimicking certain aspects of ketamine’s action, have risen out of … molecular complexities of
ketamine’s action, both basic and … understanding of ketamine’s effects in treating depression. …
ketamine’s action, both basic and … understanding of ketamine’s effects in treating depression. …
[HTML][HTML] Time is of the essence: coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine
Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating
depression and suicidal ideation. Intense research efforts have been undertaken to expose the …
depression and suicidal ideation. Intense research efforts have been undertaken to expose the …
Encoding, consolidation, and renormalization in depression: synaptic homeostasis, plasticity, and sleep integrate rapid antidepressant effects
T Rantamäki, S Kohtala - Pharmacological reviews, 2020 - ASPET
Recent studies have strived to find an association between rapid antidepressant effects and
a specific subset of pharmacological targets and molecular pathways. Here, we propose a …
a specific subset of pharmacological targets and molecular pathways. Here, we propose a …
[HTML][HTML] Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
… For statistical analysis two-sided tests including unpaired two-tailed Student’s t-test, Mann
… , Pearson’s χ 2 test and Spearman’s correlation test were used. Levene’s test was used to …
… , Pearson’s χ 2 test and Spearman’s correlation test were used. Levene’s test was used to …
[HTML][HTML] Detecting glass and metal in consumer trash bags during waste collection using convolutional neural networks
OI Funch, R Marhaug, S Kohtala, M Steinert - Waste management, 2021 - Elsevier
We present a proof-of-concept method to classify the presence of glass and metal in
consumer trash bags. With the prevalent utilization of waste collection trucks in municipal solid …
consumer trash bags. With the prevalent utilization of waste collection trucks in municipal solid …
[HTML][HTML] Cortical excitability and activation of TrkB signaling during rebound slow oscillations are critical for rapid antidepressant responses
S Kohtala, W Theilmann, M Rosenholm, L Penna… - Molecular …, 2019 - Springer
… pharmacological basis governing ketamine’s antidepressant effects. Experimental evidence
… ketamine’s therapeutic effects [12], also contributes to the enhanced AMPA-R function [13]. …
… ketamine’s therapeutic effects [12], also contributes to the enhanced AMPA-R function [13]. …
Brief isoflurane anesthesia produces prominent phosphoproteomic changes in the adult mouse hippocampus
Anesthetics are widely used in medical practice and experimental research, yet the
neurobiological basis governing their effects remains obscure. We have here used quantitative …
neurobiological basis governing their effects remains obscure. We have here used quantitative …
[HTML][HTML] Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine …
S Kohtala, W Theilmann, M Rosenholm, HK Müller… - …, 2019 - Elsevier
Subanesthetic rather than anesthetic doses are thought to bring the rapid antidepressant
effects of the NMDAR (N-methyl-d-aspartate receptor) antagonist ketamine. Among molecular …
effects of the NMDAR (N-methyl-d-aspartate receptor) antagonist ketamine. Among molecular …
[HTML][HTML] Ketamine reduces electrophysiological network activity in cortical neuron cultures already at sub-micromolar concentrations–Impact on TrkB-ERK1/2 signaling
A Ahtiainen, I Annala, M Rosenholm, S Kohtala… - …, 2023 - Elsevier
The dissociative anesthetic ketamine regulates cortical activity in a dose-dependent manner.
Subanesthetic-dose ketamine has paradoxical excitatory effects which is proposed to …
Subanesthetic-dose ketamine has paradoxical excitatory effects which is proposed to …
Virtually hosted hackathons for design research: lessons learned from the international design engineering annual (IDEA) challenge 2021
This paper provides an overview and appraisal of the International Design Engineering
Annual (IDEA) challenge - a virtually hosted design hackathon run with the aim of generating a …
Annual (IDEA) challenge - a virtually hosted design hackathon run with the aim of generating a …