[HTML][HTML] The distribution of toxic metals in the human retina and optic nerve head: Implications for age-related macular degeneration
R Pamphlett, S Cherepanoff, LK Too, S Kum Jew… - PLoS …, 2020 - journals.plos.org
Objective Toxic metals are suspected to play a role in the pathogenesis of age-related
macular degeneration. However, difficulties in detecting the presence of multiple toxic metals …
macular degeneration. However, difficulties in detecting the presence of multiple toxic metals …
[HTML][HTML] Inorganic mercury in human astrocytes, oligodendrocytes, corticomotoneurons and the locus ceruleus: implications for multiple sclerosis, neurodegenerative …
R Pamphlett, S Kum Jew - Biometals, 2018 - Springer
… ’s disease (Mutter et al. 2010) and amyotrophic lateral sclerosis (ALS) (Pamphlett and Kum
Jew … of cells contain iHg (Pamphlett and Kum Jew 2015) so this combination of methods was …
Jew … of cells contain iHg (Pamphlett and Kum Jew 2015) so this combination of methods was …
[HTML][HTML] Epigenetic differences between monozygotic twins discordant for amyotrophic lateral sclerosis (ALS) provide clues to disease pathogenesis
PE Young, S Kum Jew, ME Buckland, R Pamphlett… - PLoS …, 2017 - journals.plos.org
… We began by performing a Pearson’s correlation of methylation levels between co-twins.
Co-twin CpG methylation was highly correlated overall (r = 0.978, range 0.972–0.982), and …
Co-twin CpG methylation was highly correlated overall (r = 0.978, range 0.972–0.982), and …
[HTML][HTML] Age-related accumulation of toxic metals in the human locus ceruleus
Damage to the locus ceruleus has been implicated in the pathogenesis of a number of
neurological conditions. Locus ceruleus neurons accumulate toxic metals such as mercury …
neurological conditions. Locus ceruleus neurons accumulate toxic metals such as mercury …
[HTML][HTML] Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus
…, R Mak, J Lee, ME Buckland, AJ Harding, S Kum Jew… - PloS one, 2020 - journals.plos.org
Objective Damage to locus ceruleus neurons could play a part in the pathogenesis of
neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and multiple …
neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and multiple …
Different populations of human locus ceruleus neurons contain heavy metals or hyperphosphorylated Tau: implications for amyloid-β and tau pathology in Alzheimer's …
R Pamphlett, S Kum Jew - Journal of Alzheimer's Disease, 2015 - content.iospress.com
A marked loss of locus ceruleus (LC) neurons is a striking pathological feature of Alzheimer's
disease (AD). LC neurons are particularly prone to taking up circulating toxicants such as …
disease (AD). LC neurons are particularly prone to taking up circulating toxicants such as …
[HTML][HTML] Mercury in the retina and optic nerve following prenatal exposure to mercury vapor
R Pamphlett, S Kum Jew, S Cherepanoff - PLoS One, 2019 - journals.plos.org
Damage to the retina and optic nerve is found in some neurodegenerative disorders, but it
is unclear whether the optic pathway and central nervous system (CNS) are affected by the …
is unclear whether the optic pathway and central nervous system (CNS) are affected by the …
[HTML][HTML] Uptake of inorganic mercury by human locus ceruleus and corticomotor neurons: implications for amyotrophic lateral sclerosis
R Pamphlett, S Kum Jew - Acta neuropathologica communications, 2013 - Springer
Background Environmental toxins are suspected to play a role in the pathogenesis of
amyotrophic lateral sclerosis (ALS). In an attempt to determine which pathways these toxins can …
amyotrophic lateral sclerosis (ALS). In an attempt to determine which pathways these toxins can …
[HTML][HTML] Elemental bioimaging shows mercury and other toxic metals in normal breast tissue and in breast cancers
R Pamphlett, L Satgunaseelan, S Kum Jew, PA Doble… - PLoS …, 2020 - journals.plos.org
Objective Exposure to toxic metals such as mercury has been proposed to be a risk factor
for the development of breast cancer since some metals can promote genetic mutations and …
for the development of breast cancer since some metals can promote genetic mutations and …
[HTML][HTML] The nitroxide 4-methoxy-tempo inhibits the pathogenesis of dextran sodium sulfate-stimulated experimental colitis
B Chami, PT San Gabriel, S Kum-Jew, XS Wang… - Redox Biology, 2020 - Elsevier
Inflammatory bowel disease (IBD) is a chronic condition characterised by leukocyte recruitment
to the gut mucosa. Leukocyte myeloperoxidase (MPO) produces the two-electron oxidant …
to the gut mucosa. Leukocyte myeloperoxidase (MPO) produces the two-electron oxidant …