User profiles for S. Lelievre

Sophie Lelievre

Purdue University
Verified email at purdue.edu
Cited by 5549

Tissue structure, nuclear organization, and gene expression in normal and malignant breast

MJ Bissell, VM Weaver, SA Lelièvre, F Wang… - Cancer research, 1999 - AACR
… Given this behavioral range and the possibility that nuclear architecture itself may impart
important behavioral cues (58), we investigated whether these progressive stages of S 1 cell …

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

SK Muthuswamy, D Li, S Lelievre, MJ Bissell… - Nature cell …, 2001 - nature.com
Both ErbB1 and ErbB2 are overexpressed or amplified in breast tumours. To examine the
effects of activating ErbB receptors in a context that mimics polarized epithelial cells in vivo, we …

[PDF][PDF] β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

VM Weaver, S Lelièvre, JN Lakins, MA Chrenek… - Cancer cell, 2002 - cell.com
… the nonmalignant S-1 cells at passages 50–70 (“normal”; S-1) … Control S-1 structures in
rBM, S-1 in collagen I gels, and S-1 … B: BrdU labeling indices for S-1 cells incorporated into 3D …

Architecture in 3D cell culture: An essential feature for in vitro toxicology

SA Lelièvre, T Kwok, S Chittiboyina - Toxicology in vitro, 2017 - Elsevier
Three-dimensional cell culture has the potential to revolutionize toxicology studies by allowing
human-based reproduction of essential elements of organs. Beyond the study of toxicants …

Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus

SA Lelièvre, VM Weaver… - Proceedings of the …, 1998 - National Acad Sciences
… The antibody-directed disruption of NuMA foci in the acini induced changes in the distribution
pattern of acetylated histone H4, the activation of metalloprotease(s), and the loss of BM …

Redefining the impact of nutrition on breast cancer incidence: is epigenetics involved?

D Teegarden, I Romieu, SA Lelievre - Nutrition research reviews, 2012 - cambridge.org
… The 20-year predictions for large increases in breast cancer incidence and mortality in LMI
regions(1) substantiate the urgency of the WHO’s call for actions to support primary cancer …

High resolution protein localization using soft X‐ray microscopy

…, D Hamamoto, A Nair, SA Lelievre… - Journal of …, 2001 - Wiley Online Library
… Freezing rates of 3000 C s −1 are not sufficient to achieve vitreous ice and well-frozen cells.
Examination of the same cells using electron microscopy might reveal ice crystal damage …

Segmentation of nuclei and cells using membrane related protein markers

…, R Malladi, SA Lelievre… - journal of …, 2001 - Wiley Online Library
… Immunostaining was performed using a protocol already described (Lelièvre et al., 1998).
Mouse IgG1 anti-laminB antibody was purchased from … Bissell for providing the S 1−50 cells. …

Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells.

K Bojanowski, S Lelievre, J Markovits… - Proceedings of the …, 1992 - National Acad Sciences
The antitrypanosomal and antifiliarial drug suramin is currently under investigation for treatment
of advanced malignancies including prostatic cancer, adrenocortical cancer, and some …

Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis

…, MU Ramirez, GL Kucera, EA Levine, SA Lelievre… - Cancer research, 2021 - AACR
This study demonstrates that diet shifts the microbiome in the gut and the breast tumor
microenvironment to affect tumorigenesis, and oral dietary interventions can modulate the tumor …