User profiles for S. Lobentanzer

Sebastian Lobentanzer

Heidelberg University Hospital
Verified email at uni-heidelberg.de
Cited by 208

Integrating knowledge and omics to decipher mechanisms via large‐scale models of signaling networks

…, K Zirngibl, O Ivanova, S Lobentanzer… - Molecular systems …, 2022 - embopress.org
Signal transduction governs cellular behavior, and its dysregulation often leads to human
disease. To understand this process, we can use network models based on prior knowledge, …

Democratizing knowledge representation with BioCypher

S Lobentanzer, P Aloy, J Baumbach, B Bohar… - Nature …, 2023 - nature.com
… The ability to build a task-specific KG is important, since directly standardizing the
representation of biomedical knowledge is not appropriate for the diverse research tasks in the …

What's in a Badge? A Computational Reproducibility Investigation of the Open Data Badge Policy in One Issue of Psychological Science

…, M Elson, SJ Geiger, S Lobentanzer… - Psychological …, 2023 - journals.sagepub.com
In April 2019, Psychological Science published its first issue in which all Research Articles
received the Open Data badge. We used that issue to investigate the effectiveness of this …

Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade

…, S Lobentanzer, B Nadorp, S Dubnov… - Proceedings of the …, 2020 - National Acad Sciences
Stroke is a leading cause of death and disability. Recovery depends on a delicate balance
between inflammatory responses and immune suppression, tipping the scale between brain …

[PDF][PDF] Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder

S Lobentanzer, G Hanin, J Klein, H Soreq - Cell reports, 2019 - cell.com
RNA sequencing analyses are often limited to identifying lowest p value transcripts, which
does not address polygenic phenomena. To overcome this limitation, we developed an …

LIANA+: an all-in-one cell-cell communication framework

…, PSL Schäfer, E Farr, P Rodriguez Mier, S Lobentanzer… - BioRxiv, 2023 - biorxiv.org
… First, we implemented global Moran’s R 17 - a bivariate extension of Moran’s I used as a
simple measure of spatial co-occurrence. Such co-occurrence measures, however, only …

[HTML][HTML] Distinct CholinomiR blood cell signature as a potential modulator of the cholinergic system in women with fibromyalgia syndrome

C Erbacher, S Vaknine, G Moshitzky, S Lobentanzer… - Cells, 2022 - mdpi.com
Fibromyalgia syndrome (FMS) is a heterogeneous chronic pain syndrome characterized by
musculoskeletal pain and other key co-morbidities including fatigue and a depressed mood. …

[HTML][HTML] Drugst. One-A plug-and-play solution for online systems medicine and network-based drug repurposing

…, M Kotlyar, O Lazareva, H Levi, M List, S Lobentanzer… - Arxiv, 2023 - ncbi.nlm.nih.gov
In recent decades, the development of new drugs has become increasingly expensive and
inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood…

A platform for the biomedical application of large language models

S Lobentanzer, J Saez-Rodriguez - arXiv preprint arXiv:2305.06488, 2023 - arxiv.org
… still is restricted; we need to isolate the information that iss question and the contents of
user-provided scientific articles (or other texts). The most efficient way to do this mapping is

Central cholinergic function and metabolic changes in streptozotocin‐induced rat brain injury

T Yuliani, S Lobentanzer, J Klein - Journal of neurochemistry, 2021 - Wiley Online Library
As glucose hypometabolism in the brain is an early sign of Alzheimers dementia (AD), the
diabetogenic drug streptozotocin (STZ) has been used to induce Alzheimer‐like pathology in …