User profiles for S. Lobentanzer
Sebastian LobentanzerHeidelberg University Hospital Verified email at uni-heidelberg.de Cited by 208 |
Integrating knowledge and omics to decipher mechanisms via large‐scale models of signaling networks
Signal transduction governs cellular behavior, and its dysregulation often leads to human
disease. To understand this process, we can use network models based on prior knowledge, …
disease. To understand this process, we can use network models based on prior knowledge, …
Democratizing knowledge representation with BioCypher
… The ability to build a task-specific KG is important, since directly standardizing the
representation of biomedical knowledge is not appropriate for the diverse research tasks in the …
representation of biomedical knowledge is not appropriate for the diverse research tasks in the …
What's in a Badge? A Computational Reproducibility Investigation of the Open Data Badge Policy in One Issue of Psychological Science
In April 2019, Psychological Science published its first issue in which all Research Articles
received the Open Data badge. We used that issue to investigate the effectiveness of this …
received the Open Data badge. We used that issue to investigate the effectiveness of this …
Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade
Stroke is a leading cause of death and disability. Recovery depends on a delicate balance
between inflammatory responses and immune suppression, tipping the scale between brain …
between inflammatory responses and immune suppression, tipping the scale between brain …
[PDF][PDF] Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder
RNA sequencing analyses are often limited to identifying lowest p value transcripts, which
does not address polygenic phenomena. To overcome this limitation, we developed an …
does not address polygenic phenomena. To overcome this limitation, we developed an …
LIANA+: an all-in-one cell-cell communication framework
…, PSL Schäfer, E Farr, P Rodriguez Mier, S Lobentanzer… - BioRxiv, 2023 - biorxiv.org
… First, we implemented global Moran’s R 17 - a bivariate extension of Moran’s I used as a
simple measure of spatial co-occurrence. Such co-occurrence measures, however, only …
simple measure of spatial co-occurrence. Such co-occurrence measures, however, only …
[HTML][HTML] Distinct CholinomiR blood cell signature as a potential modulator of the cholinergic system in women with fibromyalgia syndrome
C Erbacher, S Vaknine, G Moshitzky, S Lobentanzer… - Cells, 2022 - mdpi.com
Fibromyalgia syndrome (FMS) is a heterogeneous chronic pain syndrome characterized by
musculoskeletal pain and other key co-morbidities including fatigue and a depressed mood. …
musculoskeletal pain and other key co-morbidities including fatigue and a depressed mood. …
[HTML][HTML] Drugst. One-A plug-and-play solution for online systems medicine and network-based drug repurposing
In recent decades, the development of new drugs has become increasingly expensive and
inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood…
inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood…
A platform for the biomedical application of large language models
S Lobentanzer, J Saez-Rodriguez - arXiv preprint arXiv:2305.06488, 2023 - arxiv.org
… still is restricted; we need to isolate the information that is … s question and the contents of
user-provided scientific articles (or other texts). The most efficient way to do this mapping is …
user-provided scientific articles (or other texts). The most efficient way to do this mapping is …
Central cholinergic function and metabolic changes in streptozotocin‐induced rat brain injury
As glucose hypometabolism in the brain is an early sign of Alzheimers dementia (AD), the
diabetogenic drug streptozotocin (STZ) has been used to induce Alzheimer‐like pathology in …
diabetogenic drug streptozotocin (STZ) has been used to induce Alzheimer‐like pathology in …