RNA N6-methyladenosine and the regulation of RNA localization and function in the brain
… Investigations into the roles of m 6 A in RNA biology are rapidly expanding but require
new techniques to fully understand m 6 A’s role in RNA localization in the brain. …
new techniques to fully understand m 6 A’s role in RNA localization in the brain. …
[HTML][HTML] Fear extinction is regulated by the activity of long noncoding RNAs at the synapse
…, A Periyakaruppiah, SU Madugalle… - Nature …, 2023 - nature.com
… 120 s and then extinction trained with 60 non-reinforced 120 s CS presentations with a 5 s
… B (24 h later) and presented with a 3 120 s CS with 120 s ITI. Memory was calculated as the …
… B (24 h later) and presented with a 3 120 s CS with 120 s ITI. Memory was calculated as the …
[PDF][PDF] ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3
…, EL Zajaczkowski, LJ Leighton, SU Madugalle… - Cell reports, 2022 - cell.com
Here, we used RNA capture-seq to identify a large population of lncRNAs that are expressed
in the infralimbic prefrontal cortex of adult male mice in response to fear-related learning. …
in the infralimbic prefrontal cortex of adult male mice in response to fear-related learning. …
The DNA modification N6-methyl-2'-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction
…, J Yin, SU Madugalle, Z Wang, S Nainar… - Nature …, 2019 - nature.com
… 60 non-reinforced 120 s conditioned stimulus presentations (at 5-s intervals). For behavior …
assessed during three 120 s conditioned stimulus presentations (with 120 s intertribal interval)…
assessed during three 120 s conditioned stimulus presentations (with 120 s intertribal interval)…
Synapse-enriched m6A-modified Malat1 interacts with the novel m6A reader, DPYSL2, and is required for fear-extinction memory
… s pre-fear-conditioning habituation period, which was followed by three pairings of a 120 s,
80 dB white noise conditioned stimulus (CS) with a 1 s… nonreinforced 120 s CS presentations (…
80 dB white noise conditioned stimulus (CS) with a 1 s… nonreinforced 120 s CS presentations (…
The DNA repair-associated protein Gadd45γ regulates the temporal coding of immediate early gene expression within the prelimbic prefrontal cortex and is required …
…, EL Zajaczkowski, Z Wang, SU Madugalle… - Journal of …, 2019 - Soc Neuroscience
… s, 80 dB, pure tone stimulus (CS) with a 1 s, 0.7 mA, foot shock (US), separated by an
empty 10 s … The pretrial interval, intertrial interval, and post-trial interval were all 120 s long. …
empty 10 s … The pretrial interval, intertrial interval, and post-trial interval were all 120 s long. …
Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction
…, EL Zajaczkowski, LJ Leighton, SU Madugalle… - Nature …, 2020 - nature.com
DNA forms conformational states beyond the right-handed double helix; however, the
functional relevance of these noncanonical structures in the brain remains unknown. Here we …
functional relevance of these noncanonical structures in the brain remains unknown. Here we …
Localised Cdr1as activity is required for fear extinction memory
…, Q Zhao, WS Liau, H Gong, SU Madugalle… - … of Learning and …, 2023 - Elsevier
… , pure 16 kHz tone (CS) co-terminating with a 1 s 0.7 mA foot shock (US) in CTX A. Animals
… but the ITI between CS presentations was 5 s. The percentage of time the animal remained …
… but the ITI between CS presentations was 5 s. The percentage of time the animal remained …
Fear extinction is regulated by long noncoding RNA activity at the synapse
…, PR Marshall, A Periyakaruppiah, SU Madugalle… - BioRxiv, 2022 - biorxiv.org
… HEK293T cells were maintained in a medium containing Dulbecco’s modified eagle
medium (DMEM) and high glucose (Gibco 11965) with 5% FBS and 1% penicillin-streptomycin. …
medium (DMEM) and high glucose (Gibco 11965) with 5% FBS and 1% penicillin-streptomycin. …
DNA G-quadruplex is a transcriptional control device that regulates memory
…, LJ Leighton, SU Madugalle… - Journal of …, 2024 - Soc Neuroscience
The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA.
Here we report that DNA G-quadruplex (G4-DNA) accumulates in neurons, in an experience-…
Here we report that DNA G-quadruplex (G4-DNA) accumulates in neurons, in an experience-…