User profiles for S. Marguerat
Samuel MargueratTeam Lead in Genomics, UCL Cancer Institute Verified email at ucl.ac.uk Cited by 8583 |
Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution
… To analyse the S. pombe transcriptome at the best possible resolution, we used Illumina
1G to sequence … We found no evidence for the existence of alternate splicing in S. pombe. …
1G to sequence … We found no evidence for the existence of alternate splicing in S. pombe. …
[HTML][HTML] Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells
Data on absolute molecule numbers will empower the modeling, understanding, and
comparison of cellular functions and biological systems. We quantified transcriptomes and …
comparison of cellular functions and biological systems. We quantified transcriptomes and …
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
… The expression of growth- and stress-related genes as a function of growth rate has
recently been studied in S. cerevisiae grown under steady-state conditions in chemostats …
recently been studied in S. cerevisiae grown under steady-state conditions in chemostats …
[HTML][HTML] RNA-seq: from technology to biology
S Marguerat, J Bähler - Cellular and molecular life sciences, 2010 - Springer
… RNA-seq, on the other hand, is particularly well suited for the study of mRNA processing, as
it generates transcript sequence data from a library independently of the organism’s genome …
it generates transcript sequence data from a library independently of the organism’s genome …
[PDF][PDF] The wound microenvironment reprograms Schwann cells to invasive mesenchymal-like cells to drive peripheral nerve regeneration
…, S Khadayate, AC Lloyd, S Marguerat, S Parrinello - Neuron, 2017 - cell.com
Schwann cell dedifferentiation from a myelinating to a progenitor-like cell underlies the
remarkable ability of peripheral nerves to regenerate following injury. However, the molecular …
remarkable ability of peripheral nerves to regenerate following injury. However, the molecular …
Post-transcriptional control of gene expression: a genome-wide perspective
Gene expression is regulated at multiple levels, and cells need to integrate and coordinate
different layers of control to implement the information in the genome. Post-transcriptional …
different layers of control to implement the information in the genome. Post-transcriptional …
[HTML][HTML] Proportionality: a valid alternative to correlation for relative data
…, JJ Egozcue, S Marguerat… - PLoS computational …, 2015 - journals.plos.org
… Compositional data analysis [4] (CoDA) is a valid alternative that harks back to Pearson’s
observation [5] of ‘spurious correlation’, ie, while statistically independent variables X, Y, and Z …
observation [5] of ‘spurious correlation’, ie, while statistically independent variables X, Y, and Z …
[PDF][PDF] A network of multiple regulatory layers shapes gene expression in fission yeast
… This analysis provided a consensus sequence for optimal translational initiation in S. pombe
and revealed significant correlations of the AugCAI with ribosome occupancy and density (…
and revealed significant correlations of the AugCAI with ribosome occupancy and density (…
[HTML][HTML] Coordinating genome expression with cell size
S Marguerat, J Bähler - Trends in Genetics, 2012 - cell.com
… To address this issue, genome-wide approaches that analysed gene expression and
transcriptional efficiency were recently used in S. pombe cell cycle mutants that show altered cell …
transcriptional efficiency were recently used in S. pombe cell cycle mutants that show altered cell …
Quantitative impact of thymic clonal deletion on the T cell repertoire
JPM van Meerwijk, S Marguerat, RK Lees… - The Journal of …, 1997 - rupress.org
… However, proliferation of mature CD4SP does not account for the increase as cell cycle
analysis reveals no augmentation in the number of CD4SP cells in S+G2/M phase (Fig. 3,A). A …
analysis reveals no augmentation in the number of CD4SP cells in S+G2/M phase (Fig. 3,A). A …