… Our findings exemplify a mechanism by which an RNA helicase is modulated by arginine
methylation to resolve R‐loops, and its potential role in regulating transcription. …

… We also show that PARP1 is recruited at R-loop formation sites in cells. Pharmacologic
inhibition of PARP activity and genetic ablation of PARP1 gene in cells increase the genomic R-…

… repair is no exception and, during DNA DSB repair, broken DNA is resected and exists
transiently in ssDNA form. While this is … is significantly more vulnerable to chemical modifications [ …

… We have shown previously that the DEAD box RNA helicase DDX5 is a key player in
resolving persistent unscheduled R-loops (17). Genome-wide DNA/RNA immunoprecipitation (…

DDX5, XRN2, and PRMT5 have been shown to resolve DNA/RNA hybrids (R-loops) at RNA
polymerase II transcription termination sites at few genomic loci. Herein, we perform genome…

… Consistently, overexpression of Cdc13 or introducing an additional NLS into WT Cdc13
or Cdc13-1 is not tolerated by cells (Mersaoui and Wellinger unpublished). This latter toxicity …

Deinococcus radiodurans, one of the most radioresistant organisms known to date is able to
reconstruct an intact genome from hundreds of DNA fragments. Here, we investigate the in …

… is that PRMT1 and PRMT5 share substrates. Substrate scavenging is observed when only
PRMT1 or PRMT5 is … independent of whether it is aDMA or sDMA is required for cancer …

… Using an HSP70 inhibitor, we demonstrate that the crosstalk between both pathways is
dependent on the chaperone activity. These results suggest that HSP70 availability is a key …

… However, little is known about its role at stalled replication forks. Here, we report that CSB
is recruited to stalled forks in a manner dependent upon its T1031 phosphorylation by CDK. …