There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with
the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using …

… It is interesting to mention that a mutant allele affecting the same region of the S. cerevisiae
Cdc42 protein was reported to be more than simply a null allele, having a dominant negative …

The activity of Wnt and Notch signalling is central to many cell fate decisions during
development and to the maintenance and differentiation of stem cell populations in homeostasis. …

Wnt/ß-catenin signalling is a widespread cell signalling pathway with multiple roles during
vertebrate development. In mouse embryonic stem (mES) cells, there is a dual role for ß-…

The transcription factor Oct4 is required in vitro for establishment and maintenance of embryonic
stem cells and for reprogramming somatic cells to pluripotency. In vivo, it prevents the …

… in vitro functional organs using the patient’s own cells for cell therapy, organ transplant or …
(iPSCs) derived from the patient’s fibroblasts or peripheral blood mononuclear cells (see …

The activation-induced cytidine deaminase (AID; also known as AICDA) enzyme is required
for somatic hypermutation and class switch recombination at the immunoglobulin locus 1 . In …

… Data processing using the complete pipeline with the test datasets took 8916 s for the
mouse embryo, 3408 s for the breast cancer spheroid and 26487 s for the pancreatic cancer …

The pluripotent state is traditionally associated with large absolute levels of certain transcription
factors such as Nanog and Oct4. Here, we present experimental observations using …

… This enables a 2D image to be processed in less than 10 s and a normal 3D image (for
example, 512 3 512 3 100) to be processed in less than 3 min on a workstation such as an Intel …