… The authors would like to thank the members of the Gilbert and Nachtergaele Labs for
helpful discussions. This work was supported by National Institutes of Health (NIH) grants …

… With the development of RiboMeth-seq, we can now estimate the stoichiometry of 2′OMe
in rRNA in S. cerevisiae.Citation 37 While the majority of sites are fully methylated, a small …

… A large 800-kDa enzyme complex responsible for N 6 -methylation was initially purified (12),
and soon after, MT-A70 (now known as METTL3) was identified as the main S-…

… All sequencing data that support the findings of this study have been deposited in NCBI’s
GEO under accession number GSE90639 (for RIP–seq), GSE90642 (for m 6 A-seq), and …

… (s) (Figures 5I and 5J). We then focused on these two FTO potential targets for further studies.
… The reader(s) that promotes the mRNA stability of FTO target transcripts (eg, ASB2 and …

… Importantly, upon transfer to a nitrogen-source deficient medium the S. pombe methylome
exhibited noticeable changes in the identity of methylated transcripts (some transcripts gained …

… DNA after the lesion has been excised by the nucleotide excision repair pathway 3 , while
others participate in trans-lesion synthesis to allow replication past damaged lesions in S …

… The R-2HGxFTOxm6A Axis Regulates MYC Expression To identify critical downstream
target(s) of … Consistent with R-2HG’s effects, knockdown of FTO also inhibited MYC expression; …

… (S)-OHC binding and signalling to evaluate the effect of these mutations. First, we tested
the ability of 20(S)… As previously demonstrated 7 , wild-type SMO can be captured on 20(S)-OHC …

… To test this prediction, we synthesized an analog of nat-20(S)-OHC with a terminal alkyne
group (4; nat-20(S)-yne) compatible with click chemistry techniques for coupling the molecule …