… s promoter. While the chromogranin-like protein Nesp55 is structurally and functionally not
related to Gα s , XLα s is structurally identical to Gα s … In contrast to Gα s , XLα s has a limited …

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …

… that the G i -mediated decrease in cAMP levels counteracts the antiaggregatory effects of
endothelial mediators such as PGI 2 , which increases platelet cAMP levels via its G s -coupled …

… Although it has been known for decades that the commensal metabolite butyrate suppresses
inflammation and carcinogenesis in colon, the exact identity of molecular target(s) of …

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

… Using Pearson’s correlation, we identified bacterial strains that positively correlated with
IL-18 release in vivo, signifying increased inflammasome activation, and these also correlated …

… To address whether Gpr43 plays a role in n-butyrate’s effect on LPS-induced genes, we
overexpressed Gpr43 or an empty vector control in BMDM by retroviral transduction; measured …

Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a
lipid-lowering drug 1 , 2 . The pharmacological effect of nicotinic acid requires doses that are …

… B, ligand-induced [ 35 S]GTPγS binding to membranes from untransfected CHO cells or
CHO cells stably expressing HM74a, PUMA-G, or HM74 (as indicated) by nicotinic acid (filled …

… a 10-s scheduled sampling every 5 min and used the 24-h mean values for analysis. For
analyzing the acute effects of agonists and antagonists, we collected data continuously in 5-s …