[HTML][HTML] MalDA, accelerating malaria drug discovery
The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories.
The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process …
The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process …
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas-and TNFR1-induced apoptosis
To identify novel antiapoptotic proteins encoded by DNA viruses, we searched viral genomes
for proteins that might interfere with Fas and TNFR1 apoptotic signaling pathways. We …
for proteins that might interfere with Fas and TNFR1 apoptotic signaling pathways. We …
Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
… (5) The ideal drug would target multiple stages of the parasite’s life cycle, block or prevent
transmission, or act against Plasmodium vivax liver hypnozoites. Because there are very few …
transmission, or act against Plasmodium vivax liver hypnozoites. Because there are very few …
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38
Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical drug …
cellular screening, allowing millions of compounds to be assayed and delivering clinical drug …
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Chemogenetic characterization through in vitro evolution combined with whole-genome
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …
[HTML][HTML] FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
…, M Ahmad, S Ottilie, F Bullrich, S Banks… - Journal of Biological …, 1997 - ASBMB
We identified and cloned a novel human protein that contains FADD/Mort1 death effector
domain homology regions, designated FLAME-1. FLAME-1, although most similar in structure …
domain homology regions, designated FLAME-1. FLAME-1, although most similar in structure …
[HTML][HTML] Dimerization properties of human Bad: Identification of a BH-3 domain and analysis of its binding to mutant Bcl-2 and Bcl-Xl proteins
… (s) reported in this paper has been submitted to the GenBank™/EMBL Data Bank with accession
number(s) … The nucleotide sequence(s) reported in this paper has been submitted to the …
number(s) … The nucleotide sequence(s) reported in this paper has been submitted to the …
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
… (C) IC 50 of each compound in Dd2 cells expressing S. cerevisiae DHODH normalized to
parent. The transgenic Dd2-ScDHODH strain expresses the cytosolic type 1 DHODH from S. …
parent. The transgenic Dd2-ScDHODH strain expresses the cytosolic type 1 DHODH from S. …
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target
Development of antimalarial compounds into clinical candidates remains costly and arduous
without detailed knowledge of the target. As resistance increases and treatment options at …
without detailed knowledge of the target. As resistance increases and treatment options at …
[HTML][HTML] Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
Chemical matter is needed to target the divergent biology associated with the different life
cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines …
cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines …