User profiles for S. Pattillo Smith

Samuel Pattillo Smith

Postdoctoral Research Fellow, UT- Austin
Verified email at utexas.edu
Cited by 153

Human genetic admixture through the lens of population genomics

S Gopalan, SP Smith, K Korunes… - … of the Royal …, 2022 - royalsocietypublishing.org
… population but rare in the other(s), then as that allele rises in … 12 generations of strong selection
(s = 0.05) at the adaptive … an allele that is under strong selection (s = 0.05) in the admixed …

[PDF][PDF] Characterization of prevalence and health consequences of uniparental disomy in four million individuals from the general population

P Nakka, SP Smith, AH O'Donnell-Luria… - The American Journal of …, 2019 - cell.com
Meiotic nondisjunction and resulting aneuploidy can lead to severe health consequences in
humans. Aneuploidy rescue can restore euploidy but may result in uniparental disomy (UPD…

The impact of a modified repeated-reading strategy paired with optical character recognition on the reading rates of students with visual impairments

ST Pattillo, KW Heller, M Smith - Journal of Visual Impairment …, 2004 - journals.sagepub.com
The repeated-reading strategy and optical character recognition were paired to demonstrate
a functional relationship between the combined strategies and two factors: the reading rates …

Detecting shared genetic architecture among multiple phenotypes by hierarchical clustering of gene-level association statistics

…, SP Smith, B Sandstede, S Ramachandran - Genetics, 2020 - academic.oup.com
… We did not perform this analysis for the Alzheimer’s/Dementia cluster as Alzheimer’s returned
no cross-trait heritability estimates with any other phenotype. Overall, we find that cross-…

[PDF][PDF] Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries

SP Smith, S Shahamatdar, W Cheng, S Zhang… - The American Journal of …, 2022 - cell.com
… -European ancestry cohort’s minor allele frequency and sam… (2) an LD matrix S empirically
estimated from external data (… gene-ε uses the LD matrix S to test each gene for enrichment …

[HTML][HTML] Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila

…, SP Smith, L Crawford, S Ramachandran… - PLoS …, 2021 - journals.plos.org
… also introduce PEGASUS_flies, a Drosophila-adapted version of the PEGASUS platform
first used in human studies, to infer gene-level significance of association based on the gene’s

Accounting for statistical non-additive interactions enables the recovery of missing heritability from GWAS summary statistics

SP Smith, G Darnell, D Udwin, A Harpak… - bioRxiv, 2022 - biorxiv.org
… in the stratified-LD score regression framework and its software s-LDSC 34 (Materials and
Methods). Here, s-LDSC heritability estimates still showed an increase with the interaction …

Low-temperature chemical vapor deposition of rhodium and iridium thin films

DC Smith, SG Pattillo, NE Elliott, TG Zocco… - MRS Online …, 1989 - cambridge.org
Low-temperature chemical vapor deposition of M(allyl)3 (M = Rh, Ir; allyl = η3 -C3H5) in the
presence of H• yields thin, crystalline metal films of greater than 97% metal composition. …

Tradeoffs in Modeling Context Dependency in Complex Trait Genetics

E Weine, SP Smith, RK Knowlton, A Harpak - bioRxiv, 2023 - biorxiv.org
… In essence, ash takes in a vector of effect estimates ˆβ and a vector of corresponding
standard errors s, estimates a prior distribution of the true effects p(β), and then uses this prior to …

Hierarchical clustering of gene-level association statistics reveals shared and differential genetic architecture among traits in the UK Biobank

…, S Pattillo Smith, B Sandstede, S Ramachandran - bioRxiv, 2019 - biorxiv.org
… We then concatenate together each phenotype’s feature vector to generate a phenotype by
gene matrix, the ultimate input for the WINGS software. In our analyses of the UK Biobank, a …