User profiles for S. Pattillo Smith
Samuel Pattillo SmithPostdoctoral Research Fellow, UT- Austin Verified email at utexas.edu Cited by 153 |
Human genetic admixture through the lens of population genomics
… population but rare in the other(s), then as that allele rises in … 12 generations of strong selection
(s = 0.05) at the adaptive … an allele that is under strong selection (s = 0.05) in the admixed …
(s = 0.05) at the adaptive … an allele that is under strong selection (s = 0.05) in the admixed …
[PDF][PDF] Characterization of prevalence and health consequences of uniparental disomy in four million individuals from the general population
Meiotic nondisjunction and resulting aneuploidy can lead to severe health consequences in
humans. Aneuploidy rescue can restore euploidy but may result in uniparental disomy (UPD…
humans. Aneuploidy rescue can restore euploidy but may result in uniparental disomy (UPD…
The impact of a modified repeated-reading strategy paired with optical character recognition on the reading rates of students with visual impairments
ST Pattillo, KW Heller, M Smith - Journal of Visual Impairment …, 2004 - journals.sagepub.com
The repeated-reading strategy and optical character recognition were paired to demonstrate
a functional relationship between the combined strategies and two factors: the reading rates …
a functional relationship between the combined strategies and two factors: the reading rates …
Detecting shared genetic architecture among multiple phenotypes by hierarchical clustering of gene-level association statistics
… We did not perform this analysis for the Alzheimer’s/Dementia cluster as Alzheimer’s returned
no cross-trait heritability estimates with any other phenotype. Overall, we find that cross-…
no cross-trait heritability estimates with any other phenotype. Overall, we find that cross-…
[PDF][PDF] Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries
… -European ancestry cohort’s minor allele frequency and sam… (2) an LD matrix S empirically
estimated from external data (… gene-ε uses the LD matrix S to test each gene for enrichment …
estimated from external data (… gene-ε uses the LD matrix S to test each gene for enrichment …
[HTML][HTML] Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila
… also introduce PEGASUS_flies, a Drosophila-adapted version of the PEGASUS platform
first used in human studies, to infer gene-level significance of association based on the gene’s …
first used in human studies, to infer gene-level significance of association based on the gene’s …
Accounting for statistical non-additive interactions enables the recovery of missing heritability from GWAS summary statistics
… in the stratified-LD score regression framework and its software s-LDSC 34 (Materials and
Methods). Here, s-LDSC heritability estimates still showed an increase with the interaction …
Methods). Here, s-LDSC heritability estimates still showed an increase with the interaction …
Low-temperature chemical vapor deposition of rhodium and iridium thin films
DC Smith, SG Pattillo, NE Elliott, TG Zocco… - MRS Online …, 1989 - cambridge.org
Low-temperature chemical vapor deposition of M(allyl)3 (M = Rh, Ir; allyl = η3 -C3H5) in the
presence of H• yields thin, crystalline metal films of greater than 97% metal composition. …
presence of H• yields thin, crystalline metal films of greater than 97% metal composition. …
Tradeoffs in Modeling Context Dependency in Complex Trait Genetics
… In essence, ash takes in a vector of effect estimates ˆβ and a vector of corresponding
standard errors s, estimates a prior distribution of the true effects p(β), and then uses this prior to …
standard errors s, estimates a prior distribution of the true effects p(β), and then uses this prior to …
Hierarchical clustering of gene-level association statistics reveals shared and differential genetic architecture among traits in the UK Biobank
…, S Pattillo Smith, B Sandstede, S Ramachandran - bioRxiv, 2019 - biorxiv.org
… We then concatenate together each phenotype’s feature vector to generate a phenotype by
gene matrix, the ultimate input for the WINGS software. In our analyses of the UK Biobank, a …
gene matrix, the ultimate input for the WINGS software. In our analyses of the UK Biobank, a …