The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to
evaluate the diagnosis and therapy of short stature in children. Forty-six international experts …

… S and complete loss of the POU-HD, are predicted to lose DNA-binding.39, 83 The A158P
mutant in the POU-S … within the alpha helices of the POU-S or POU-HD would not be expected …

… Invagination of the oral ectoderm leads to the creation of Rathke’s pouch. Intensified cell
proliferation within Rathke’s pouch results in formation of the anterior pituitary lobe. …

Insulin resistance and elevated glucagon levels result in nonsuppressible hepatic glucose
production and hyperglycemia in patients with type 2 diabetes. The CREB coactivator …

… Detailed analyses have suggested that both the POU-S and POU-HD contact DNA, with
the POU-S domain required for highaffinity, site-specific binding and DNA-dependent …

… A second steroid-dependent mechanism has also been proposed, in which E 2 ’s positive
neurotropic effects contribute to the maturation of the GnRH pulse generator during puberty (9)…

… Dana S Hardin, MD Dana S Hardin … Sally Radovick …

… To test whether metformin could directly affect mitochondrial complex’s activity, we conducted
in vitro assays and assessed metformin’s effect on the complex’s activity by using purified …

… Any new initiative would need to incorporate: i) appropriate comparison population(s) to
permit more direct assessment of outcomes between GH-exposed and non-treated groups; ii) …

Early in the pathogenesis of type 2 diabetes mellitus (T2DM), dysregulated glucagon secretion
from pancreatic α cells occurs prior to impaired glucose-stimulated insulin secretion (GSIS…