Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating new
insulin-producing cells from other cell types is a major aim of regenerative medicine. One …

… state of the cell, there is mounting evidence that the converse is also true, that metabolite …
The Sdelci lab’s contributions to this study were funded by the European Union’s Horizon …

The NIMA‐family kinases Nek9/Nercc1, Nek6 and Nek7 form a signalling module required
for mitotic spindle assembly. Nek9, the upstream kinase, is activated during prophase at …

… We now show that the single phosphorylation of NEDD1 on Ser377 by Nek9 is essential
for this process. NEDD1[Ser377A] is not recruited to the centrosome in mitosis and it does not …

The histone acetyl reader bromodomain-containing protein 4 (BRD4) is an important regulator
of chromatin structure and transcription, yet factors modulating its activity have remained …

… Taken together, the results reported in this study show that ERK5 is … that PKC is neither a
positive nor a negative regulator of CSF-1-induced ERK5 activation, confirming that ERK5 is not …

… Our results indicate that loss of electron transport chain (ETC) enzymes is synthetically viable
with etoposide and that some of the ETC enzymes are partially located on chromatin 24 h …

… To clarify which BET target is responsible for RFP repression and rule out off-target effects,
we knocked down all the (S)-JQ1 targets individually in the REDS3 clone and quantified RFP-…

Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent
contribution of epigenetics to the development of this disease. To uncover new synthetic …

… Mechanistically, we show that the AR is a substrate for γ-carboxylation, a post-translational
modification inhibited by PPC. Collectively, our data suggest that PPC could be repurposed …