Background Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia
and now poses a threat to the control and elimination of malaria. Mapping the geographic …

… s at 94 C, 90 s at 60 C, 90 s at 72 C and final extension 10 min at 72 C. PCR products
were detected by 2% agarose gel electrophoresis and ethidium bromide staining. Double-strand …

… ≤ j ≤ 7) a score S ij equal to the maximum F ST across all qualifying SNPs. The score S i
for the gene was then calculated as the arithmetic mean of S ij across the seven comparisons. …

Background Artemisinin resistance in Plasmodium falciparum lengthens parasite clearance
half-life during artemisinin monotherapy or artemisinin-based combination therapy. Absence …

… -wide F ST = 1 − (Π S / Π T ), where Π S is the average correspondence within the two …
From applying the estimators for π S and π T at each of the 86,128 SNPs, we derive genome…

Background Artemisinin resistance in Plasmodium falciparum threatens to reduce the efficacy
of artemisinin combination therapies (ACTs), thus compromising global efforts to eliminate …

Background Artemisinin-resistant Plasmodium falciparum has been reported in Pailin,
western Cambodia, detected as a slow parasite clearance rate in vivo. Emergence of this …

… Using parasitised blood samples from these studies, we measured piperaquine IC 50 s ex
… The GWAS was designed to identify genetic markers of raised piperaquine IC 50 s, whereas …

Background The emergence and spread of resistance in Plasmodium falciparum malaria to
artemisinin combination therapies in the Greater Mekong subregion poses a major threat to …

Background Artemisinin and partner-drug resistance in Plasmodium falciparum are major
threats to malaria control and elimination. Triple artemisinin-based combination therapies (…