The recent outbreak of the corona virus disease (COVID-19) has had major global impact.
The relationship between severe acute respiratory syndrome coronavirus (SARS-CoV-2) …

Evaluation and optimization of drug metabolism and pharmacokinetic data plays an important
role in drug discovery and development and several reliable in vitro ADME models are …

Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall
elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database …

… Definitive assessment of a compound’s clearance mechanisms takes place during a human
… It should be emphasized that a drug’s predominant elimination process such as metabolism, …

Therapeutic approaches to slow or block the progression of Parkinson disease (PD) do not
exist. Genetic and biochemical studies implicate α-synuclein and leucine-rich repeat kinase 2 …

Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson’s disease (PD)
by genome-wide association studies (GWAS). The most common LRRK2 mutation, …

The Biopharmaceutics Classification System (BCS) is a scientific framework that provides a
basis for predicting the oral absorption of drugs. These concepts have been extended in the …

The kinase-activating mutation G2019S in leucine-rich repeat kinase 2 (LRRK2) is one of the
most common genetic causes of Parkinson’s disease (PD) and has spurred development …

… Nevertheless, through comprehensive validation, we may better understand the model’s
shortfalls and benefits so allowing it to propagate ground-breaking discoveries in clinical …

… (pK a ’s = 4−5) at the peroxisomal pH of ∼8.2. High-throughput screening of our compound
file against the human DAAO enzyme uncovered lead compounds with pK a ’s > 8 that are …