Background Pathological complete response has been proposed as a surrogate endpoint
for prediction of long-term clinical benefit, such as disease-free survival, event-free survival (…

… To test for a trend between n strata (eg, of age) in the effects of treatment, we supposed
that stratum number s (s=1,2,…,n) has log-rank statistics (o–e) and v (with grand total over all …

Aberrant receptor expression or functioning of the epidermal growth factor receptor (Erbb)
family plays a crucial part in the development and evolution of cancer. Inhibiting the signalling …

Background We present the combined results of two trials that compared adjuvant
chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-…

BACKGROUND Doxorubicin is a highly effective and widely used cytotoxic agent with
application that is limited by cardiotoxicity related to the cumulative dose of the drug. A large‐scale …

Background The anti–human epidermal growth factor receptor 2 (HER2) humanized monoclonal
antibody trastuzumab improves the outcome in patients with HER2-positive metastatic …

Background In patients with metastatic breast cancer that is positive for human epidermal
growth factor receptor 2 (HER2), progression-free survival was significantly improved after first-…

Interferon-γ is key in limiting Mycobacterium tuberculosis infection. Here we show that
vaccination triggered an accelerated interferon-γ response by CD4 + T cells in the lung during …

… There is some controversy about the benefits of a biopsy in situations where there is no doubt
about the nature of the lesion(s) and where all receptors were positive in the primary tumor…

A Monte Carlo technique has been used to calculate the electron distribution functions in the
(000) and (100) valleys of gallium arsenide. This method avoids having to make any of the …