We use high-density single nucleotide polymorphism (SNP) genotyping microarrays to
demonstrate the ability to accurately and robustly determine whether individuals are in a complex …

… discovery Bayes factor, where K s is the Bayes factor for polymorphism discovery for the s
th base as derived in equation 2> (see Methods). An example plot of K s across each base (of …

Background Approximately 90% of persons with amyotrophic lateral sclerosis (ALS) have
the sporadic form, which may be caused by the interaction of multiple environmental factors …

Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified …

We conducted a systematic study of top susceptibility variants from a genome-wide
association (GWA) study of bipolar disorder to gain insight into the functional consequences of …

We sequenced the genomes of 200 individuals from 41 families multiply affected with bipolar
disorder (BD) to identify contributions of rare variants to genetic risk. We initially focused on …

An overall burden of rare structural genomic variants has not been reported in bipolar disorder
(BD), although there have been reports of cases with microduplication and microdeletion. …

We report the development and validation of experimental methods, study designs, and
analysis software for pooling-based genomewide association (GWA) studies that use high-…

Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities.
Risk for BD is genetically encoded and overlaps with systems that maintain circadian …

… for future contact, as well as the names, addresses and telephone numbers of two individuals
likely to know the subject’s future whereabouts, and the subject’s driver’s license number. …